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- ArticleMartin R, Schon F, Lamarche Y.Ann Anesthesiol Fr. 1979;20(1):19-24.Fifteen cases of patients referred for treatment of acute and chronic pain problems are reported. The results show that both epidural and peripheric hypertonic frozen saline 5 p. 100 injections were effective, as far as three months afterwards. The possible mechanism of action of frozen saline is discussed.