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  • Book
    by Robert J. Hilt, Abraham M. Nussbaum.
    Contents:
    Addressing behavioral and mental problems in community settings
    Common clinical concerns
    The 15-minute pediatric diagnostic interview
    The 30-minute pediatric diagnostic interview
    DSM-5 pediatric interview
    A brief version of DSM-5
    A stepwise approach to differential diagnosis
    The mental state examination : a psychiatric glossary
    Selected DSM-5 assessment measures
    Rating scales and alternative diagnostic systems
    Developmental milestones
    Mental health treatment planning
    Psychosocial interventions
    Psychotherapeutic interventions
    Psychopharmacology
    Ideas for practice, education, and research.
    Digital Access PsychiatryOnline 2016
  • Article
    Wu AM, Platt T.
    Proc Natl Acad Sci U S A. 1978 Nov;75(11):5442-6.
    We have determined the RNA and DNA sequences in the region specifying termination of transcription at the end of the tryptophan (trp) operon of Escherichia coli. A 3'-terminal mRNA fragment of about 150 nucleotides yielded oligonucleotide products that could be assigned to the end of trpA (the last structural gene in the operon) by correlation with the amino acid sequence of the protein product. Analysis of the DNA corresponding to this region served to align the few noncoding RNA oligonucleotide sequences and demonstrated that termination of trp transcription occurs in vivo at a site 36 nucleotides after trpA, with greater than 95% efficiency. In two different strains partially defective in the transcription termination factor rho, the purified transcript is much longer and more complex, suggesting that a significant amount of read-through occurs in these strains. This is consistent with evidence [Guarente, L. P., Mitchell, D. H. & Beckwith, J. (1977) J. Mol. Biol. 112, 423-436] that efficient termination in vivo at the end of the trp operon is a rho-dependent event. The trp terminator (trp t) shares several features with other known sites of transcription termination, including (i) a 3'-terminal RNA sequence of several uridine residues, C-A-U-U-U-U(OH), (ii) a G.C-rich region in the DNA immediately preceding the site of termination, followed by an A.T-rich region, and (iii) a region of dyad symmetry in the DNA which, in the transcript, is capable of forming a stable hairpin containing seven G.C base pairs and one A.U base pair in its stem.
    Digital Access Access Options