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  • Book
    editors, Mark T. Gladwin, Gregory J. Kato, Enrico Novelli.
    Summary: "This book will provide students and practitioners with the most recent guidelines for patient care. Chapters include guidelines of care, diagnosis, unique cases, and cutting-edge therapies that will appeal to hematology fellows, trainees, and practicing hematologists"-- Provided by publisher

    Contents:
    Genetic Basis of Sickle Cell Disease / Martin H Steinberg, Swee Lay Thein
    Sickle Hemoglobin Polymerization / Daniel B. Kim-Shapiro, Constance Tom Noguchi, Alan N. Schechter
    Vaso-Occlusion in Sickle Cell Disease / Huihui Li, Paul Frenette
    Hemolysis and Endothelial Dysfunction / Gregory J. Kato, Mark T. Gladwin
    Sterile Inflammation in Sickle Cell Disease / Prithu Sundd, Solomon F. Ofori-Acquah
    Ischemia-Reperfusion Pathobiology in Sickle Cell Anemia / Robert P. Hebbel, John D. Belcher, Gregory M. Vercellotti
    Mechanistic Insights on Sickle Cell Pathophysiology Learned From Transgenic Mouse Models / Kalpna Gupta, Lewis L. Hsu
    Pharmacologic Induction of Fetal Hemoglobin / Abdullah Kutlar, Vivien Sheehan
    Stroke and Cognitive Dysfunction / Hanne Stotesbury, Robert J. Adams, Fenella J. Kirkham
    Management of Pregnant Women and Newborns With Sickle Cell Disease / Samuel A. Oppong, Jodi-Anne Stewart, Michael R. DeBaun
    The Asthma Conundrum in Sickle Cell Disease / Natalie R. Shilo, Elizabeth S. Klings, Claudia R. Morris
    Acute Chest Syndrome / Armand Mekontso Dessap, Elliott Vichinsky
    Pediatric Sickle Cell Disease / John J. Strouse, Nancy Green
    Pulmonary Hypertension and Heart Disease in Patients with Sickle Cell Disease / Mark T. Gladwin, Kenneth I. Ataga, Roberto Machado
    Cardiac Complications / Vandana Sachdev, Punam Malik, John Wood
    Sickle Nephropathy / Santosh L. Saraf, Vimal K. Derebail, Victor R. Gordeuk, Jane A. Little
    Sickle Cell Trait / Philippe Connes, Hyacinth I. Hyacinth, Rakhi P. Naik
    Acute and Chronic Pain / Samir K. Ballas, Wally R. Smith
    Priapism in Sickle Cell Disease / Susan M. MacDonald, Arthur L. Burnett
    Ocular Complications in Sickle Cell Disease / Adrienne W. Scott, Morton F. Goldberg Rare Presentations and Emerging Complications of Sickle Cell Disease / Oswaldo Castro, Kathryn L. Hassell
    Thrombophilia in Sickle Cell Disease / Enrico Novelli, Rafal Pawlinski, Sruti Shiva, Nigel Key
    Transfusion Therapy in Sickle Cell Disease / Sally A. Campbell-Lee, Anoosha Habibi, Darrell J. Triulzi
    Clinical Trials : State of the Art and Lesson Learned / Laura M. De Castro, Ramasubramanian Kalpatthi, Marilyn J. Telen
    Hematopoietic Stem Cell Transplantation in Sickle Cell Disease / Alexis Leonard, John F. Tisdale, Lakshmanan Krishnamurti, Mark C. Walters
    Emergent Clinical Complications of Sickle Cell Disease / Marcus Carden, Jeffrey Glassberg, Claudia R. Morris
    Psychosocial Burden in Sickle Cell Disease / Allison A. King, Sherif M. Badawy, Julie Panepinto, Kofi Anie, Charles Jonassaint, Marsha Treadwell
    Therapeutic Options and Combination Therapy / Caterina P. Minniti, Jane S. Hankins
    Gene Therapy for Sickle Cell Disease / Tim M. Townes, Marina Cavazzana
    Hydroxyurea and Sickle Cell Disease / Winfred C. Wang, Russell E. Ware
    The Burden of Sickle Cell Gene in India / Yazdi Italia, Dipty Jain, Roshan Colah, Khushnooma Italia
    Sickle Cell Disease in Jamaica : Observations from a Small Island / Graham Serjeant, Beryl Serjeant
    Sickle Cell Disease in Brazil / Fernando Ferreira Costa
    Sickle Cell Disease in Africa / Amma Twumwa Owusu-Ansah, Julie Makani, Kwaku Ohene-Frempong.
    Digital Access AccessHemOnc 2021
  • Article
    Prime SS, Toh BH.
    J Cell Sci. 1978 Oct;33:329-40.
    The distribution of concanavalin A (Con A) surface receptors and cytoplasmic actin in the same cell was studied in monolayer cultures of 2 odontogenic epithelial cells of different developmental age and in ecto-mesenchymal cells derived from the same tooth germ. Con A receptors were demonstrated by fluorescein-isothiocyanate-labelled Con A (FITC-Con A) and cytoplasmic actin by a specific anti-actin autoantibody (AAA) traced with a rhodamine-labelled goat anti-human globulin (R-AHG). All 3 cell types, incubated with FITC-Con A at 37 degrees C for increasing time periods, showed progressive changes in staining patterns from clusters, caps to perinuclear globules. Capping was seen in the majority of immature epithelial cells at 120--180 min, in cells of more mature epithelium at 180--240 min and in ecto-mesenchymal cells at 240--360 min. Binding of FITC-Con A to cell surfaces resulted in sequential changes in AAA staining from filamentous to an aggregated or diffuse pattern, co-capping of aggregated or diffusely stained areas with those capped by FITC-Con A, presence of aggregated or diffusely stained areas in sites similar to the perinuclear globules stained by FITC-Con A, to final re-emergence of filamentous staining. Prior treatment of cells with cytochalasin B or colchicine promoted capping in epithelial but not in ecto-mesenchymal cells while presence of either drug throughout the staining procedure inhibited capping. The results show that Con A receptors are more mobile in epithelial compared to ecto-mesenchymal cells and in immature epithelial cells compared to their more mature counterparts, and that binding and mobility of Con A receptors on the cell surface is associated with redistribution of cytoplasmic actin. The cytochalasin B and colchicine experiments suggest that both microfilaments and microtubules may have synergistic roles in the opposing functions of receptor anchorage and mobility, and that the relative receptor immobility of ectomesenchymal compared to epithelial cells may be attributed to firmer receptor anchorage to the cytoskeleton.
    Digital Access Access Options