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  • Book
    [edited by] Bruce A. Chabner, MD, Professor of Medicine, Harvard Medical School, ... Show More Director of Clinical Research, Massachusetts General Hospital Cancer Center, Boston, Massachusetts, Dan L. Longo, MD, Professor of Medicine, Harvard Medical School, Senior Physician, Brigham and Woman's Hospital, Deputy Editor, New England Journal of Medicine, Boston, Massachusetts.
    Summary: Offers an overview of the medications and approaches used in cancer care. This book features numerous tables and succinct, outline-style text that puts important information at your fingertips.

    Contents:
    Introduction: Considerations for cancer pharmacotherapy
    Antimetabolites: nucleoside and base analogs / Bruce A. Chabner
    Antifolates / Bruce A. Chabner
    The taxanes, vinca alkaloids, and their derivatives / Bruce A. Chabner
    Topoisomerase inhibitors: camptothecins, anthracyclines, and etoposide / Bruce A. Chabner
    Adduct-forming agents: alkylating agents and platinum analogs / Bruce A. Chabner
    Immunomodulatory drugs and proteasome inhibitors / Anuj Mahindra, Hamza Mujagic, Bruce A. Chabner
    Natural products: bleomycin and trabectedin / Bruce A. Chabner
    L-asparaginase / Bruce A. Chabner
    Differentiating agents / Bruce A. Chabner
    Molecular targeted drugs / Benjamin Izar, Jeffrey W. Clark, Bruce A. Chabner
    Antiestrogens / Tanja Badovinac Crnjevic, Paul E. Goss
    Antiandrogen therapy / Bruce A. Chabner
    Interferons / Dan L. Longo
    Cytokines, growth factors, and immune-based interventions / Dan L. Longo
    Monoclonal antibodies in cancer treatment / Dan L. Longo
    Osteoclast-targeted therapy: bisphosphonates and denosumab / Matthew R. Smith
    Febrile neutropenia / Stephen M. Carpenter, Fabrizio Vianello, Mark C. Poznansky
    Anemia / Zuzana Tothova, James Bradner
    Cancer and coagulopathy / Rachel P.G. Rosovsky
    Metabolic emergencies in oncology / Ephraim Paul Hochberg
    Pain management / Juliet Jacobsen, Vicki Jackson
    Comprehensive end-of-life care / Jennifer Shin, Jennifer Temel
    Depression, anxiety, and fatigue / Carlos G. Fernandez-Robles, William F. Pirl
    Acute myeloid leukemia / Amir T. Fathi
    Myelodysplastic syndromes / Eyal C. Attar
    Myeloproliferative neoplasms / Jerry L. Spivak
    Chronic myeloid leukemia / Karen Ballen
    Acute lymphoblastic leukemia and lymphoma / James W. Fraser, Janet E. Murphy, Eyal C. Attar
    Chronic lymphocytic leukemia/small lymphocytic lymphoma / Philip C. Amrein
    Plasma cell disorders / Noopur Raje, Dan L. Longo
    Diffuse large B-cell lymphoma / Jennifer Gao, Ephraim Paul Hochberg
    Hodgkin's disease / Dan L. Longo
    Follicular lymphoma / Amy Sievers, Ann LaCasce
    Mantle cell lymphoma / Dan L. Longo
    Peripheral T-cell lymphomas / Jeffrey A. Barnes, Jeremy S. Abramson
    Uncommon B-cell lymphomas / Jeremy S. Abramson, Jeffrey A. Barnes
    Immunology of hematopoietic stem cell transplantation / Srinivas Viswanathan, Yi-Bin Chen
    Overview of clinical bone marrow transplantation / Sarah Nikiforow, Thomas R. Spitzer
    Renal cell carcinoma / M. Dror Michaelson
    Localized prostate cancers / Jason A. Efstathious, Phillip J. Gray, Douglas M. Dahl
    Metastatic prostate cancer / Matthew R. Smith
    Bladder cancer / Richard J. Lee
    Testicular cancer / Timothy Gilligan
    Esophageal and gastric cancer / Lawrence S. Blaszkowsky
    Pancreatic cancer / Jeffrey W. Clark
    Cholangiocarcinoma and gallbladder cancers / Janet E. Murphy, Andrew X. Zhu
    Colon cancer / David P. Ryan
    Rectal cancer / Theodore S. Hong
    Anal cancer / Jennifer Wo
    Malignant mesothelioma / Lee M. Krug, Pasi A. Jänne
    Non-small cell lung cancer / Justin F. Gainor, Jeffrey A. Engelman
    Small cell lung cancer / Anna F. Farago, Rebecca Suk Heist
    Thymoma / Panos Fidias
    Ovarian cancer / Richard T. Penson
    Primary squamous carcinoma of the uterine cervix: diagnosis and management / Olivia Foley, Marcela G. del Carmen
    Uterine Cancer / Don S. Dizon
    Breast oncology: clinical presentation and genetics / Amy Comander, Tessa Cigler, Paula D. Ryan
    Localized breast cancer / Beverly Moy
    Metastatic breast cancer / Steven J. Isakoff
    Melanoma / Ryan J. Sullivan, Krista Rubin, Donald Lawrence
    Soft tissue and bone sarcomas / Edwin Choy, Sam S. Yoon, Francis J. Hornicek, Thomas F. DeLaney
    Primary brain tumors / Andrew S. Chi
    Metastatic brain tumors / April F. Eichler
    Paraneoplastic neurologic syndromes / Jorg Dietrich
    Thyroid cancer / Lori J. Wirth, Tito Fojo
    Adrenocortical cancer / Tito Fojo
    Head and neck cancer / Lori J. Wirth, Paul M. Busse, Daniel Deschler.
    Digital Access AccessHemOnc 2014
  • Article
    Dessau W, Sasse J, Timpl R, Jilek F, von der Mark K.
    J Cell Biol. 1978 Nov;79(2 Pt 1):342-55.
    Fibronectin, the major cell surface glycoprotein of fibroblasts, is absent from differentiated cartilage matrix and chondrocytes in situ. However, dissociation of embryonic chick sternal cartilage with collagenase and trypsin, followed by inoculation in vitro reinitiates fibronectin synthesis by chondrocytes. Immunofluorescence microscopy with antibodies prepared against plasma fibronectin (cold insoluble globulin [CIG]) reveals fibronectin associated with the chondrocyte surface. Synthesis and secretion of fibronectin into the medium are shown by anabolic labeling with [35S]methionine or [3H]glycine, and identification of the secreted proteins by immunoprecipitation and sodium dodecyl sulfate (SDS)-disc gel electrophoresis. When chondrocytes are plated onto tissue culture dishes, the pattern of surface-associated fibronectin changes from a patchy into a strandlike appearance. Where epithelioid clones of polygonal chondrocytes develop, only short strands of fibronectin appear preferentially at cellular interfaces. This pattern is observed as long as cells continue to produce type II collagen that fails to precipitate as extracellular collagen fibers for some time in culture. Using the immunofluorescence double-labeling technique, we demonstrate that fibroblasts as well as chondrocytes which synthesize type I collagen and deposit this collagen as extracellular fibers show a different pattern of extracellular fibronectin that codistributes in large parts with collagen fibers. Where chondrocytes begin to accumulate extracellular cartilage matrix, fibronectin strands disappear. From these observations, we conclude (a) that chondrocytes synthesize fibronectin only in the absence of extracellular cartilage matrix, and (b) that fibronectin forms only short intercellular "stitches" in the absence of extracellular collagen fibers in vitro.
    Digital Access Access Options