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- BookCharlotte C. Teneback, Bryan Garcia, editors.Summary: This book offers an in-depth and up-to-date review of bronchiectasis. Bronchiectasis is a broadly heterogenous disease with a variety of etiologies and disease phenotypes and endotypes. To comprehensively and adequately address bronchiectasis, all these aspects need to be considered, which is not always the case in the current literature. Throughout this book, expert authors discuss the epidemiology, etiology, clinical management and clinical trials to give the reader greater context and tools to care for their patients. Chapters include coverage of environmental and infectious causes of bronchiectasis, radiographic phenotyping, diagnosing, and monitoring of bronchiectatic diseases, and host directed therapy. This is an ideal guide for pulmonologists and trainees caring for patients with bronchiectasis.
Contents:
Bronchiectasis: An Introduction to the Patient from the Clinician's Perspective
Global epidemiology and impact of bronchiectasis in adults without cystic fibrosis
Systemic diseases associated with Bronchiectasis
Environmental and Infectious causes of Bronchiectasis
Approach to Etiological Diagnosis and Initial Management
Radiographic Phenotyping, Diagnosing, and Monitoring of Bronchiectatic Diseases
Acute Exacerbations of Bronchiectasis and the Airway Microbiology
Host-Directed Therapy
Challenges and Considerations for Clinical Trials Design in Bronchiectasis
Non-CF Bronchiectasis and Nontuberculous Mycobacteria: Integration of Mental Health and Quality of Life into Patient Care. - ArticleAndersson KE, Forman A.Acta Pharmacol Toxicol (Copenh). 1978;43 Suppl 2:90-5.A short review is given of the effects of prostaglandins on the smooth muscle of the bladder, urethra and ureter. In several animal species and in man, prostaglandins of the E and F types contract the detrusor. The contractions develop slowly and are not affected by tetrodotoxin, phenoxybenzamine, or atropine, suggesting a direct effect on the smooth muscle cell. However, evidence is also available suggesting a role of the prostaglandins as modulators of transmitter release in the bladder. In animals as well as in man, urethral smooth muscle is contracted by prostaglandin F2alpha, but relaxed by prostaglandins E1 and E2. The smooth muscle of the ureter seems to react similarly, but published results vary. The detailed mode of action, and the role of prostaglandins in the control of activity in urinary tract smooth muscle remain to be established.