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  • Book
    Jeimylo de Castro, Yasser El Miedany, editors.
    Summary: This book is an in depth guide to chronic and neuropathic pain. The issue of chronic and neuropathic pain is very prevalent, yet only a fraction of the symptoms and root causes, as well as potential treatment plans, are properly understood. Additionally, less than half of cases are accurately identified and properly treated. The existing drugs, although classified as very strong and powerful, cannot provide lasting relief to chronic and neuropathic pain. Thus, with all the unique features of this condition, this book presents a systematic way of diagnosing and approaching this condition so every practitioner can appropriately treat their patients. In addition to introducing key concepts, like classification of chronic pain and the challenges patients and practitioners face when dealing with and treating chronic and neuropathic pain, this book will also cover different syndromes that can lead to neuropathic pains. It also discusses how to monitor progress by using outcome measures, the presence of chronic and neuropathic pain in children and young adults, and the pathophysiology of neuropathic pain as it relates to the release of pro-inflammatory cytokines. Interestingly, the latter is not presently addressed except with the usual pain drugs for general painthis book aims to revolutionize the approach to chronic and neuropathic pain by exploring it separately from the clinical approach to general pain. It is interesting to note that these cytokines require a specific mode of action if we want to neutralize them in our system, and this concept will be discussed in the regenerative intervention sections. Since it is so necessary to address the many factors to chronic and neuropathic pain as laid out in the proposed table of contents, it is also critical include as varied authors as possible to address this condition from all areas being covered. The team assembled to author the chapters included in this text come from diverse backgrounds of practice and clinical and research interests, from physical medicine and rehabilitation to anesthesiology to radiology and interventional pain medicine. This is an ideal guide for all clinicians caring for patients with chronic and neuropathic pain.

    Contents:
    Section 1: Understanding Chronic and neuropathic pain
    Classification of Chronic pain
    The Challenges in Dealing with Chronic and Neuropathic Pains
    Section 2: Pathophysiology
    The Pathophysiology of Chronic Pains
    The Pathophysiology of Neuropathic Pain
    Section 3: Age and Pain
    Pain in Children and Young Adults
    Pain in older adults
    Section 4: Pain processing medical problems
    Cancer and Pain
    Degenerative Diseases and Pain
    Complex Regional Pain Syndromes
    Neuropathic Pain Syndromes
    Fibromyalgia as a Neuropathic Pain Disorder
    Section 5: Clinical Matters
    Clinical Assessment
    Diagnostic testing of neuropathic pain
    Outcome Measures for chronic Pain
    Section 6: Management of chronic and neuropathic pains
    Non-Pharmacologic Modalities to Chronic and Neuropathic Pains
    Pharmacologic Approaches to Chronic and Neuropathic Pains
    Section 7: Interventional Therapy
    Interventional Procedures for Chronic and Neuropathic Pains
    Regenerative Interventions in Chronic and Neuropathic Pains.
    Digital Access Springer 2022
  • Article
    Vorherr H.
    Klin Wochenschr. 1978 Dec 01;56(23):1139-45.
    A controversy exists in regard to thyroid function and breast cancer. Hypothyroidism has been suggested as being either protective from breast cancer or predisposing to the disease. It has been hypothesized that a deficiency in circulating thyroid hormones may hypersensitize the mammary glandular epithelium toward prolactin and estrogens, thus aiding the development of breast neoplasia. On the other hand, thyroid hormone replacement therapy has been connected with an increased risk of breast cancer, but this has been contested. At this time the American Thyroid Association recommends that, if indicated, hypothyroid patients should take their thyroid hormone medication. Hyperthyroidism has been associated with a decreased risk of breast cancer. Also, in hyperthyroid patients with inoperable breast cancer, the malignant growth is thought to be slowed. However, this, too has been disputed. Moreover, hyperthyroidism has been connected with the development of breast cancer in premenopausal women. At present no role of thyroid hormone in the pathobiology of breast cancer can be defined. It seems that the "thyroid-breast cancer controversy" can only be resolved by a prospective study preferably on postmenopausal women correlating thyroid (T3, T4, PBI), pituitary (TSH, TRH, Prolactin), and adrenocortical (androgens) function tests with the clinical examination of thyroid, breast, and genital apparatus and determination of the estrogen status (vaginal smear, plasma estrogens) as well.
    Digital Access Access Options