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  • Book
    [edited by] Karen L. Whalen ; collaborating editors, Sarah M. Lerchenfeldt, Chris R. Giordano.
    Summary: "Students' favorite review resource for studying the essentials of medical pharmacology, Lippincott® Illustrated Reviews: Pharmacology, 8th Edition, presents up-to-date drug information in an accessible format ideal for effective review.Part of the popular Lippincott® Illustrated Reviews series, this concise resource features clear writing and hundreds of illustrations that break down complex pharmacological information, so it is understandable and accessible. Sequential images present mechanisms of action and focus on showing rather than telling students how drugs work, and review questions with answers deliver powerful, practical exam preparation. NEW! Pharmacogenomics chapter familiarizes students with this topical area of clinical pharmacology. NEW! Clinical Application boxes emphasize the practical application of pharmacology concepts with real-world clinical examples. NEW! Chapter Summaries facilitate quick review for better student comprehension. Updated drug information reflects the most current, clinically relevant pharmacology material. Approachable outline format distills complex information for easier review. High-quality illustrations reinforce understanding in vibrant detail. Enhanced review questions with answers provide valuable self-assessment and prepare students for their Board reviews"-- Provided by publisher.
    Digital Access LWW Health Library 2023
  • Article
    Zager RA, Carpenter CB.
    Kidney Int. 1978 Jun;13(6):505-12.
    A human proximal renal tubular epithelial antigen (designated HRTE-1) was isolated and purified from a crude tubular preparation (Fx1A) by a process of salt fractionation, DEAE anion-exchange chromatography, and Sephadex G-200 gel filtration. Utilizing 125I-HRTE-1 and a rabbit antiserum specific for the proximal tubular brush border, as determined by immunofluorescent microscopy, a radioimmunoassay by competitive protein-binding was developed. HRTE-1 was demonstrated in serum and urine and in extracts of a variety of body organs. A range of concentrations for normal random urine samples and 24-hr urine excretion rates were determined. Random urine samples from 36 patients with a variety of functional and pathologic renal disorders were assayed for the HRTE-1 antigen. Twenty-three of 24 patients with either chronic nephropathy or pre-renal azotemia had normal urinary antigen concentrations, despite wide differences in urine flow rates, the degree of existing renal function, and the amount of proteinuria. Ten of 12 patients with acute tubular necrosis, however, had statistically abnormal HRTE-1 concentrations (high in eight patients, undetectable in two). These findings suggest that HRTE-1 antigen can be detected in both normal and pathologic urines, that altered antigen concentrations can be documented in at least one renal disorder, and that quantitation of HRTE-1 in urine may have clinical value as a marker of acute rubular injury.
    Digital Access Access Options