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  • Book
    Wendy C. Ziai, Christy L. Cornwell, editors.
    Summary: This book provides a comprehensive and concise, review of the fundamental concepts and clinical indications for Transcranial Doppler (TCD) imaging. An overview of the physics of ultrasonography as it pertains to TCD is presented, as well as neuroanatomy and cerebrovascular physiology in healthy and diseased states. Recommended protocols for neuroimaging are reviewed and serves as a guide for existing neurovascular laboratories and medical systems seeking to develop laboratories that are in need of a guide to establish their own protocols. The most common, relevant and challenging clinical conditions where TCD is incorporated to assist with patient management are discussed. In addition, chapters provide a framework for building a neurovascular laboratory, including necessary equipment, steps to obtain national accreditation by accrediting bodies, and reimbursement procedures for tests performed. The book concludes with "clinical pearls" and "tricks of the trade", which serve as a commentary to guide physicians and neurosonologists on best-practices for TCD acquisition and interpretation.

    Contents:
    Principles of Transcranial Doppler Sonography
    Overview of Pertinent Cerebral Vascular Anatomy
    Cerebral Waveforms for Hemodynamic assessment
    Monitoring in Neurocritical Care – Overview
    Transcranial Doppler in Subarachnoid Hemorrhage
    Reversible Cerebral Vasoconstriction Syndrome (RCVS) and Vasculitis
    MONITORING FOR EMBOLI DETECTION (without and with MICROBUBBLES)
    EVALUATION OF CEREBRAL CIRCULATORY ARREST
    Intracranial Stenosis
    Therapeutic TCD for patients with acute cerebral ischemia
    Clinical Application of Cerebrovascular Physiology
    Adult Traumatic Brain Injury
    Traumatic Brain Injury : Pediatric
    Cerebrovascular Reactivity Assessments in Traumatic Brain Injury
    Transcranial Doppler Protocols and Procedures: Vasomotor Reactivity
    Continuous Cerebral Autoregulation Monitoring using TCD
    Optic Nerve Sheath Diameter for Increased Intracranial Pressure
    Cranial Ultrasound
    Applications of Transcranial Doppler Ultrasonography in Sickle Cell Disease, Stroke, and Critical Illness in Children
    Point of care Transcranial Doppler
    CEREBROVASCULAR PHYSIOLOGY IN THE SETTING OF TEMPORARY AND DURABLE MECHANICAL CIRCULATORY SUPPORT
    Electroencephalography versus Transcranial Doppler Ultrasonography; Indications and Applications for Intracranial Monitoring
    Moyamoya Disease
    Vertebral Steal
    Transcranial Doppler in Acute Bacterial Meningitis
    TCD equipment, Lab Accreditation, Reimbursement, and Practice Issues
    Use of Transcranial Doppler in the Outpatient Ultrasound Lab
    Protocol for Non- Imaging Transcranial Doppler
    Transcranial Color Doppler Imaging for Adults
    Protocol for Monitoring for Emboli Detection (and with Microbubbles)
    How to obtain measurements of the optic nerve sheath diameter in adults and children utilizing point-of-care ophthalmic ultrasonography
    Protocol for Extracranial Carotid Exam.
    Digital Access Springer 2022
  • Article
    Robertson RP, Guest RJ.
    J Clin Invest. 1978 Nov;62(5):1014-9.
    These studies were designed to examine whether interrelationships exist between serotonin and prostaglandin E (PGE) during regulation of insulin secretion in dogs in vivo. In our studies serotonin was found to inhibit insulin responses to intravenous glucose. This inhibition was not reversed by complete adrenergic blockade provided through combined phentolamine and propranolol pretreatment. This property of serotonin is similar to that of PGE which also inhibits glucose-induced insulin secretion in vivo independently of adrenergic activity. To investigate whether these effects of serotonin and PGE are related, studies with methysergide (a serotonin antagonist) and indomethacin (a PGE synthesis inhibitor) were performed. Methysergide reversed the effects of both PGE and serotonin. In contrast, indomethacin did not diminish the inhibitory effect of serotonin upon insulin secretion. It is hypothesized that endogenous serotonin may play a role in the inhibitory effect of PGE upon insulin secretion in dogs in vivo.
    Digital Access Access Options