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  • Book
    Christopher J. VanderBussche, Carla L. Ellis, editors.
    Summary: This book covers the full spectrum of benign and malignant conditions of the genitourinary tract with emphasis on common entities encountered in daily practice. The volume is heavily illustrated and contains useful algorithms that guide the reader through the differential diagnosis and cyto-histologic correlation of common and uncommon entities with appropriate clinical correlations. This book will serve as a valuable quick reference for pathologists, cytopathologists, cytotechnologists, fellows and residents in the field. Genitourinary system cytopathology specimens and small biopsies are common specimens, with a growing number of renal fine needle aspirations and core biopsy procedures being performed each year. Genitourinary System Cytology and Small Biopsy Specimens focuses on the correlation between urinary tract cytology and surgical pathology, including the evaluation of germ cell tumor metastasis to distant sites. Aspiration and exfoliative cytology samples obtained from all areas of and related to the genitourinary tract are highlighted in individualized chapters for these entities. The growing body of information in personalized medicine and molecular discoveries in the field of genitourinary pathology demands focus as well; hence an integrated approach to molecular diagnostics is presented in each chapter. In summary, this book will provide an illustrative and algorithmic approach to every day practice of genitourinary cytopathology and small biopsy material, using appropriate cytologic-histologic correlation format and incorporating recent updates in terminology, guidelines, and ancillary studies.

    Contents:
    Urinary Tract Exfoliative Cytology & Biopsy Specimens: Non-Neoplastic Findings
    Urinary Tract Exfoliative Cytology & Biopsy Specimens: Low Grade Urothelial Neoplasms
    Urinary Tract Exfoliative Cytology & Biopsy Specimens: High Grade Urothelial Carcinoma
    Urinary Tract Exfoliative Cytology & Biopsy Specimens: Other Urothelial Tract Neoplasms
    Renal Fine Needle Aspiration & Core Biopsy Specimens: Renal Cell Carcinomas
    Renal Fine Needle Aspiration & Core Biopsy Specimens: Urothelial Carcinoma and other Non-Renal Malignancies
    Renal Fine Needle Aspiration & Core Biopsy Specimens: Benign Entities and Non-Neoplastic Findings
    Adrenal Gland
    Fine Needle Aspiration & Core Biopsy Specimens: Germ Cell Neoplasms
    Miscellaneous Lesions of the Genitourinary System.
    Digital Access Springer 2022
  • Article
    Horvat A.
    J Cell Physiol. 1978 Oct;97(1):37-47.
    Preliminary investigations (Horvat et al., '75) indicated the nucleus of rat liver as a site for specific binding of insulin. In this report these observations are confirmed. Nuclei from rat liver were isolated in a highly purified state as verified by interference contrast and electron microscopy and by chemical analysis. Extensive scanning of the preparations did not reveal the presence of structures resembling plasma membranes. The nuclear envelope was isolated by a modification of the method of Kay et al. ('72). Electron micrographs showed the presence of nuclear "ghosts" and few other recognizable nuclear elements, but no plasma membranes (60--80 A thick) were detected. The preparation was found to contain specific insulin binding activity. Specificity of the binding sites for insulin was demonstrated in competition studies with other polypeptide hormones and a synthetic insulin analog. Scatchard analysis of the binding data indicates the presence of a single class of high affinity receptors. In contrast to findings with plasma membranes the hormone-receptor complex is very stable and the kinetics of the dissociation of bound [125I]-insulin do not indicate negative cooperativity of the binding sites. Immunofluorescent labeling of intact, unfixed nuclei showed a specific fluorescent halo only around those nuclei that have been preincubated with insulin. All other controls were negative.
    Digital Access Access Options