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  • Book
    Paolo Martelletti, editor.
    Summary: This book on migraine is the first machine-generated scientific book in medicine published by Springer Nature, and reflects a new publication format which focuses on literature reviews: state-of-the-art computer algorithms were applied to select relevant sources from Springer Nature journal articles, rearrange them in a topical order, and provide short summaries of these articles. The result is the auto-summarization of current texts, organized by means of a similarity-based clustering routine in coherent chapters and sections. The human intervention of a world-renowned expert in this field grants the scientific soundness and appropriate organization of the contents identified. The AI-based approach seemed especially suitable to provide an innovative perspective as the topics are indeed both complex, interdisciplinary and multidisciplinary, as is migraine, the most important among the chronic non communicable diseases under the age of 50s. The result of this innovative process will be of help especially for readers with limited time, interested in migraine and wishing to learn more about the subject quickly and particularly if they are new to the topic. Springer Nature seeks to support anyone who needs a fast and effective start in their content discovery journey: from the undergraduate student exploring interdisciplinary content, to Master or PhD-thesis developing research questions, to the practitioner seeking support materials, this book can serve as an inspiration, to name a few examples. .

    Contents:
    Public Health: Epidemiology
    Personal and Societal Impact
    Economics of Migraine
    Governance of Headache Centers. Mechanisms: Genetics
    Biology
    Comorbidities.Lifestyle
    Hormones
    Drug-Drug Interactions. Diagnosis: Classification
    Medical History
    Medication Overuse
    Differential Diagnosis
    Diagnostic Tools: Treatment: Guidelines
    Acute
    Preventive
    Non-pharmacological
    Invasive and non-invasive neuromodulation
    Emergency Management
    Pregnancy
    Childhood and Adolescent
    Elderly
    Outcome Measures and Algorithms
    Infrequent Migraine subtypes. Future Research Directions: Brain Traumas Brain Traumas
    Post-CoVID Epidemiology
    New drugs.
    Digital Access Springer 2022
  • Journal
    Digital Access Full text via HathiTrust, 1st-
  • Article
    Kagawa H, Asai H.
    J Biochem. 1978 Oct;84(4):957-63.
    The diffusion phenomena of myosin (myosin A, H-meromyosin or subfragment-1) in F-actin plus ATP solutions were investigated. The upper part of the diffusion cell was filled with F-actin plus ATP, and the lower part was filled with F-actin, ATP, and myosin, then both parts were brought into contact so that a boundary of the two solutions was formed and the diffusion of myosin in F-actin plus ATP solutions started. The diffusion pattern was observed with a schlieren lens system. When almost all the ATP in the lower part of the cell had been consumed by actomyosin, a hyper-sharp schlieren pattern appeared near the boundary. On analyzing this pattern, it was found that a local fast migration of proteins was occurring. Simple Brownian motion of myosin molecules could not explain the hyper-sharp phenomenon. This phenomenon occurred in ther pesence of Mg2+ or Ca2+, but very little in the presence of EDTA. Although it is well known that the superprecipitation of myosin B suspension occurs only at physiological ionic strength, this phenomenon occurred over a relatively wide range of ionic strengths. The molecular mechanism of this phenomenon is discussed in relation to the basic mechanism of the interaction between myosin and F-actin.
    Digital Access Access Options