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  • Book
    C. Venkata S. Ram, Boon Wee Jimmy Teo, Gurpreet S. Wander, editors.
    Summary: This book will cover all aspects of hypertension and the manifestations of cardiovascular disease in the Asian population. Asia has the largest population of all the continents, and also has the largest number of people suffering from these diseases. Due to an expanding economy and increasing affluent lifestyles, their incidence is increasing at alarming rates - in fact, this continent is a ticking time bomb for HTN and CVD outbreaks. The book fills a large gap, as there are currently no volumes on this topic - and provides much-needed information for physicians not only in Asia but globally. Not only physicians, but also all related medical professionals and libraries will benefit from this book, to which renowned international experts contributed.

    Contents:
    1 Hypertension, a powerful risk factor for excess mortality and premature morbidity in Asia.-2 Summary of Recent Guidelines for hypertension.-3 Mechanisms of Hypertension
    4 Blood pressure levels and cardiovascular disease
    5 What is new in the non-pharmacological approaches to hypertension control
    6 Clinical Pharmacology of anti-hypertensive drugs
    7 Newer angiotensin receptor blockers
    8 Newer calcium channel blockers
    9 Blood Pressure measurements in clinical practice ---- methods and application
    10 True resistant hypertension: Recognition and treatment.-11 Cerebrovascular disease in Asia; causative factors
    12 Hypertension as a mechanism for dementia
    13 Blood pressure and Heart Rate Variability. What is the significance
    14 Blood Pressure levels and chronic kidney disease: A Powerful link
    15 Hypertension, diabetes, and metabolic syndrome
    16 Central aortic blood pressure, a possible marker of systemic hypertension.-17 Secondary causes of hypertension: An overview
    18 Iatrogenic causes of blood pressure elevation.-19 Renovascular Hypertension --- diagnosis and treatment options
    20 Mechanical interventional therapies for hypertension: Present status and future prospects
    21 Hypertensive disorders in pregnancy
    22 Hypertension in the elderly --- Pathophysiology and clinical significance
    23 Hypertension in children
    24 Hypertensive crises --- diagnostic and therapeutic considerations.
    Digital Access Springer 2022
  • Article
    Clayton RN, Vrionides Y, Lynch SS, Butt WR, London DR.
    Acta Endocrinol (Copenh). 1978 Nov;89(3):469-82.
    The long term effects of bromocriptine in 12 acromegalics treated for a mean duration of 10.2 months are reported. Seven showed a significant (P less than 0.05) and sustained fall in serum immunoreactive growth hormone (GH) levels throughout 24 h, 6 of whom had a 50% or greater reduction in mean circulating GH during glucose tolerance testing. Only one patient had mean serum GH levels throughout the day suppressed to normal (less than 5 mIU/l) but 3 had suppression of mean serum GH during GTT to normal or very near normal (less than 10 mIU/l). The effective dose was 20 mg daily. Only 4 patients reported any improvement in soft tissue swelling and acral features, which was unrelated to the GH response. Possible reasons for the discrepancy between clinical and biochemical responses are discussed. In 9 of the 12 patients bromocriptine was discontinued and pituitary ablative therapy offered. Three out of 4 patients who underwent trans-sphenoidal hypophysectomy had mean GH levels during GTT reduced to less than 7 mIU/l. In the three who continued bromocriptine treatment GH suppression was maintained at less than 10 mIU/l for up to 3 years but with little change in acral features. Although bromocriptine is safe and was well tolerated it is not as effective as existing forms of pituitary ablative therapy and should be reserved for those cases where ablation is contraindicated or unsuccessful.
    Digital Access Access Options