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  • Book
    Xian-Cheng Jiang, editor.
    Summary: This book provides an up-to-date review of the fundamentals of sphingolipid metabolism and its role in metabolic diseases. Focusing on the sphingolipid de novo synthesis pathway, the effect of sphingomyelin, ceramide, and sphingosine-1-phosphate, and linkage between sphingolipids and other lipids, such as cholesterol, it covers serine palmitoyltransferase, ceramide synthases, ceramidases, sphingosine kinases, and sphingomyelin synthases, and more. While highlighting how rare diseases related to abnormal glycosphingolipid metabolism, this publication introduces sphingolipid metabolism-related diseases, such as lung diseases and cancers, as well as sphingolipid circadian regulation. The book demonstrates advances and limitations of research on sphingolipid metabolism and its roles in metabolic diseases and other diseases. It offers graduate students and researchers a coherent overview of sphingolipids, as well as the limitations of current research in the field, and promotes further studies on metabolic diseases, as well as pharmaceutical research on drug discovery based on sphingolipid de novo synthase.

    Contents:
    Chapter 1: Sphingolipids and Cholesterol
    Chapter 2: Sphingolipids in adipose: kin or foe?
    Chapter 3: De novo sphingolipid biosynthesis in atherosclerosis
    Chapter 4: Serine Palmitoyltransferase Subunit 3 and Metabolic Diseases
    Chapter 5: Molecular mechanisms of sphingolipid transport on plasma lipoproteins
    Chapter 6: Sphingosine 1-phosphate metabolism and signaling
    Chapter 7: Sphingomyelin synthase family and phospholipase Cs
    Chapter 8: Sphingolipid metabolism and signaling in endothelial cell functions
    Chapter 9: Cholesterol metabolism in chronic kidney disease: physiology, pathologic mechanisms, and treatment
    Chapter 10: Sphingolipids and asthma
    Chaper 11: Manifold Roles of Ceramide Metabolism in Nonalcoholic Fatty Liver Disease and Liver Cancer
    Chapter 12: Drug development in the field of sphinogolipid metabolism
    Chapter 13: Rare diseases in glycosphingolipid metabolism.
    Digital Access Springer 2022
  • Article
    Kraushaar J, Pfitzer P.
    Urol Int. 1978;33(4):205-12.
    Cytologic examinations of kidneys, which were frozen for preservation in a nitrogen atmosphere below 3 ata, show a considerable damage of the cells. This does not only occur by significant reduction in the amount of isolated cells, but also in the loss of the ability to form cell colonies. DNA measurements show, however, that after 3--4 days the DNA amounts in surviving cells are intact. In one of the cultures we even found DNA values, which stand for a DNA synthesis. Experiments with mechanical perfusion alone show that this procedure results in a severe damage of the cells, only about one-third of these cells being able to form colonies.
    Digital Access Access Options