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  • Book
    Justin R. Mascitelli, Mandy J. Binning, editors.
    Summary: This book aims to cover the majority of neurovascular diseases and management. The first section reviews neurovascular anatomy, the basics of angiography, and the basics of craniotomies for neurovascular diseases. Next, an entire section is devoted to intracranial aneurysms, covering the natural history, subarachnoid hemorrhage, endovascular management, microsurgical management, and vasospasm. Following this, a number of chapters are devoted to stroke including natural history, mechanical thrombectomy, intracranial stenosis, Moyamoya disease, bypass surgery, vertebrobasilar insufficiency, intracerebral hemorrhage, sinus thrombosis, and the surgical and endovascular management of extracranial carotid disease. Next, the text covers vascular malformations including arteriovenous malformation, arteriovenous fistulas, carotid cavernous fistulas, vein of Galen malformations, spinal malformations, and cavernous malformations. Finally, the book discusses a few miscellaneous topics including more recent advances in neurovascular care such as venous sinus stenting for idiopathic intracranial hypertension and middle meningeal artery embolization for subdural hematoma. Written by experts in the field, Introduction to Vascular Neurosurgery provides a comprehensive summary of neurovascular disease and management. The book can be used as a daily reference and serves as a trusted resource for medical students, residents, fellows, and young attendings.

    Contents:
    Vascular Anatomy of the Brain
    Vascular Anatomy of the Neck/Spine
    Basics of Angiography
    Basics of Craniotomy
    Presentation and Natural history
    Subarachnoid Hemorrhage Management and External Ventricular Drain Placement
    Endovascular Aneurysm Treatment
    Microsurgical Aneurysm Treatment
    Vasospasm background and treatment
    Acute Ischemic Stroke Presentation, Natural History, and Treatment
    Endovascular Management Of Stroke
    Carotid Endarterectomy
    Endovascular Management of Extracranial Carotid Disease
    Intracranial Atherosclerotic Disease Background and Treatment
    Moyamoya Disease Background and Treatment
    Posterior Circulation Stroke and Vertebrobasilar Insufficiency
    Intracerebral Hemorrhage Background and Management
    Sinus Thrombosis Background and Management
    Presentation And Natural History Of Arteriovenous Malformations Of The Brain
    Arteriovenous Malformations Treatment and Management
    Dural Arteriovenous Fistulas
    Carotid Cavernous Fistulas And Vein Of Galen Malformations
    Spinal Vascular Malformations Background and Management
    Background and Management of Cerebral Cavernous Malformations
    Venous Sinus Stenting for Idiopathic Intracranial Hypertension
    Middle Meningeal Embolization for Subdural Hematoma
    Embolization of Head, Neck, and Spinal Tumors
    Balloon Test Occlusion, Wada test and Inferior Petrosal Sinuses Sampling.
    Digital Access Springer 2022
  • Article
    Lengeler J, Steinberger H.
    Mol Gen Genet. 1978 Aug 17;164(2):163-9.
    The synthesis of the transport systems (enzymeII-complexes) coded for in the mtl and in the gut (srl) operon was found to be induced by unphosphorylated D-mannitol and D-glucitol respectively. Induction from the outside however is only possible if these polyols are taken up into the cells. Induction of the D-mannitol system is immediate, resistant against catabolite repression, relatively insensitive towards transient repression and starts from a high uninduced level (5--30%). By contrast, the induction of the D-glucitol system starts at a low basal level (0.5--2.5%), does show a pronounced lag from 25 to 90 min, and is hypersensitive towards catabolite and transient repression. These differences apparently reflect primarely differences in the corresponding operator-promotor genes mtl (P,O) and gut (P,O) as well as differences in the uptake of the first, inducing hexitol molecules. For each operon additional regulatory genes exist, called mtlR and gutR respectively, in which transrecessive, temperature sensitive mutations leading to a constitutive expression of the corresponding operon can be found. The influence of these regulatory mechanisms in diauxie experiments and their importance for the differentiation of the three operons during evolution from apparently one common ancestor operon will be discussed.
    Digital Access Access Options