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  • Book
    D.S. Deenadayal, Vyshanavi Bommakanti.
    Summary: There are many books describing in detail the evaluation, diagnosis and management of OSA, but this is a first practical guide which comprehensively describes this condition. The incidence of snoring and obstructive sleep apnea is on rise and this practical guide will help not just specialists but also residents and fellows in treating their patients with Obstructive sleep apnea. Essential information is summarized in the form of charts and surgical steps are summarized in the form of diagrammatic illustration making it easy for the learners. This book additionally would help the medical practitioners to get a practical insight in the management of patients. This book will describe each entity of sleep disordered breathing, evidence based protocols , diagnostic tools required for identifying , medical therapies that will help in appropriate patients, Devices that can be used for its management . This book will also describe on how to select patients for surgery and how tailor the surgery as per the anatomy of the patient.

    Contents:
    1. History of snoring and obstructive sleep apnea
    2. Relevant anatomy and pathophysiology
    3. History and clinical examination in patients with OSAHS
    4. Investigations
    5. Conservative Management
    6. Medical therapies
    7. Oral appliances
    8. Myofunctional therapy
    9. Surgery for OSA
    10. Perioperative management
    11. Postoperative management and follow up
    12. Results : definition of success
    13. Medicolegal aspects and Consent in OSA surgeries
    14. Newer technological tools in the management of OSA
    15. Recent advances
    16. Interesting cases: Management.
    Digital Access Springer 2022
  • Article
    Unger RH.
    Metabolism. 1978 Nov;27(11):1691-709.
    The current controversy concerning the role of glucagon in the pathogenesis of diabetes is reviewed. The traditional "unihormonal abnormality concept," namely, that all of the metabolic derangements of diabetes are the direct consequence of deficient insulin secretion or activity, and the newer so-called bihormonal abnormality hypothesis, proposing that the fullblown diabetic syndrome requires, in addition to the insulin abnormality, a relative glucagon excess, are scrutinized. The relationship of insulin deficiency to the A-cell malfunction of diabetes, the conflicting evidence concerning the essential role of glucagon in mediating the marked overproduction of glucose and ketones in severe insulin deficiency and the contribution of glucagon to the endogenous hyperglycemia of diabetics without insulin deficiency are examined. Finally, the possibility that therapeutic suppression of diabetic hyperglucagonemia may make possible better control of hyperglycemia than is presently attainable by conventional therapeutic methods is considered. It is concluded that (1) although insulin lowers glucagon levels, restoration to normal of the A-cell dysfunction of diabetes requires that plasma insulin levels vary appropriately with glycemic change; (2) that glucagon mediates the severe endogenous hyperglycemia and hyperketonemia observed in the absence of insulin; (3) that in diabetics in whom insulin is present but relatively fixed an increase in glucagon causes hyperglycemia and glycosuria; and (4) that glucagon suppression could be a potentially useful adjunct to conventional antihyperglycemic treatment of diabetics.
    Digital Access Access Options