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  • Book
    Marian C. Hawkey, Sandra B. Lauck, editors.
    Summary: This book serves as the go-to resource for cardiovascular nurses and other health care practitioners involved in the care of patients with acquired valvular heart disease. It includes unique information about heart valve anatomy and pathophysiology, the complexity of clinical presentations and diagnostic evaluation, patient education and shared decision-making, surgical and transcatheter treatment options, and transition to palliative care. The content focuses primarily on the specialized care of patients with aortic stenosis and regurgitation, and mitral and tricuspid regurgitation. In addition, this unique resource provides timely information to guide a patient-centred and team-driven approach that reflects contemporary and innovative practice in the management of valvular heart disease. The essential topics of strengthening the multidisciplinary Heart Team and programmatic processes of care, the priorities for nursing care, and the multifactorial challenges of managing this complex patient population are explored in detail. Importantly, this resource aims to support all clinicians who are involved in the various timepoints of patients full trajectory of care, from their evaluation pathway, admissions for treatment, and long term follow-up. Clinicians require contemporary knowledge and evidence to guide their practice, provide appropriate care for this complex patient population, and contribute to the advancement of practice. To date, there has been little emphasis placed on the management of valvular heart disease in cardiovascular nursing and allied health curriculum. This book fills this gap and addresses the pressing need for a user-friendly resource to guide the care for this growing population in a rapidly changing clinical environment. The editors are international leaders in the care and management of patients with acquired valvular heart disease and program development. They are widely recognized for their pioneering role in shaping the way we care for these patients.

    Contents:
    Chapter 1: Introduction and Objectives
    Section 1: Understanding Valvular Heart Disease
    Chapter 2: Overview of Patient Population
    Chapter 3: Pathophysiology of Valvular Heart Disease
    Section 2: Valvular Heart Disease Program Structure
    Chapter 4: The Multidisciplinary Heart Team Approach
    Chapter 5:Processes of Care for Valvular Heart Disease Programs
    Section 3: Assessing Valvular Heart Disease
    Chapter 6: Clinical Assessment
    Chapter 7: Imaging Modalities
    Chapter 8: Understanding Function, Frailty and Self-Reported Health Status
    Chapter 9: Making a High Quality Treatment Decision: Shared Decision-Making
    Section 4: Treatment Options for Valvular Heart Disease and Implications for Nursing
    Chapter 10: Surgical Treatment
    Chapter 11: Transcatheter Treatment
    Section 5: Nursing Care Priorities Valvular Heart Disease
    Chapter 12: Safe Recovery after Valvular Heart Surgery
    Chapter 13: Safe Recovery after Transcatheter Heart Valve Procedures
    Chapter 14:Transitions of Care and Long Term Follow-Up after Heart Valve Surgery and Transcatheter Procedures
    Chapter 15: Conclusion: The Next Decade of Treating Valvular Heart Disease An Opportunity for Nursing Leadership.
    Digital Access Springer 2022
  • Journal
    Digital Access Full text via HathiTrust, no. 1-12, Oct. 1866-July 1869; [n.s.],v. 1-41 (no. 1-286), Jan. 1870-July 1910.
  • Article
    Gerhard W, Webster RG.
    J Exp Med. 1978 Aug 01;148(2):383-92.
    Antigenic variants of A/PR/8/34 [HON1] influenza virus were selected after a single passage of the parent virus in embryonated chicken eggs in the presence of monoclonal antibodies to this virus. The monoclonal antibodies were produced by a hybridoma and were specific for an antigenic determinant on the HA molecule of the parent virus. Seven antigenic variants were analyzed with 95 monoclonal anti-HA antibodies prepared in vitro in the splenic fragment culture system. Three subgroups of antigenic variants were distinguished. The antigenic changes were primarily recognized by monoclonal antibodies to the strain- specific determinants of the parental hemagglutinin (HA) molecule. Monoclonal antibodies to HA determinants shared (in an identical or cross-reactive form) by parental virus and more than three heterologous viruses of the HON1 and H1N1 subtypes were unable to recognize the antigenic change on the variants. Similarly, heterogeneous antibody preparations could not differentiate between parental and variant viruses. The results are compatible with the idea that the HA of PR8 has available a large repertoire of antigenic modifications that may result from single amino acid substitutions, and that antigenic changes can occur in the strain- specific determinants on the HA molecule in the absence of concomitant changes in the cross-reactive HA determinants. The findings suggest that antigenic drift, in order to be epidemiologically significant, probably requires a series of amino acid substitutions in, or close to, the antigenic area on the HA molecule.
    Digital Access Access Options