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- JournalSummary: A peer-reviewed, online-only, open access journal. Publishes engaging and informative content that catalyzes dialogue on state-of-the-art comprehensive care for patients with inflammatory bowel disease (IBD) alongside the latest research to advance prevention, treatment and cures. The journal provides a forum for the dissemination of novel insights and innovations across key disciplines involved in IBD care.Digital Access Oxford v. 1-, 2019-
- ArticleLo TC, Bewick MA.J Biol Chem. 1978 Nov 10;253(21):7826-31.Previous communications from this laboratory have indicated that dicarboxylic acid transport in Escherichia coli is an active process, and that at least three genes are responsible for this transport system. In attempts to identify the transport components, one periplasmic binding protein and two membrane integral proteins (SBP 1 and SBP 2) were implicated to participate in the transport system in vivo. In the present communication, we demonstrate, through biochemical analysis of the transport mutants, that the two membrane transport genes, dctA and dctB, are responsible for the two membrane-bound dicarboxylate binding proteins, SBP 2 and SBP 1, respectively. We also find that the substrate recognition sites of SBP 1 and SBP 2 are exposed to the inner and outer surfaces of the membrane, respectively. This may have important implications for the role of SBP 1 and SBP 2 in the translocation process.