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  • Book
    editor, Werner Zimmerli.
    Summary: "The prevalence of most bone and joint infections is steadily increasing, mainly due to the rising life expectancy of the population, and the increasing use of bone fixation devices and prosthetic joints. For frequent infectious diseases, such as respiratory tract, urinary tract and bloodstream infections, many diagnostic and therapeutic aspects have been studied in a controlled fashion [e.g. 1-3]. In contrast, in the field of bone and joint infections, randomized controlled trials are rare. Exceptions are a randomized controlled study on the role of rifampin in patients with orthopedic implant-associated infections, and a controlled trial comparing two different durations of antibiotic treatment in patients with vertebral osteomyelitis [4, 5]. Therefore, diagnostic and therapeutic advice has to be based mainly on individual clinical expert knowledge and observational studies [6-10]. The optimal diagnostic and therapeutic management of bone and joint infections needs a special know-how in different fields of medicine. Many physicians have only limited clinical experience, since arthritis and osteomyelitis are rare infectious diseases. Therefore, a multidisciplinary approach to these infections is desirable. Only for a few topics, internationally accepted guidelines for the management of bone and joint infections are available [11-13]. In addition, publications on the clinical practice comprising different aspects of these infections are scarce. The aim of this book is to close this gap with texts from a multidisciplinary team of experts in the field. Indeed, specialists in Microbiology, Clinical Pharmacology, Preclinical Research, Pediatrics, Pediatric and Adult Orthopedic Surgery, Infectious Diseases, and Cardiovascular Surgery contributed to this book. This broad spectrum of expertise made it possible to cover a wide range of pathophysiological, epidemiological, diagnostic and therapeutic aspects of bone and joint infection. The principal focus of the book is on clinical practice. It should enable clinicians managing patients according to the best available evidence"-- Provided by publisher

    Contents:
    Diagnostic Approach in Bone and Joint Infections
    Unusual Microorganisms in Periprosthetic Joint Infection
    Identification of Pathogens in Bone and Joint Infections by Non-Culture Techniques
    Bacteriophages for treatment of biofilm infections
    Pharmacokinetics and Pharmacodynamics of Antibiotics in Bone
    Preclinical Models of Infection in Bone and Joint Surgery
    Native Joint Arthritis in Children
    Native Joint Arthritis in Adults
    Septic Arthritis of Axial Joints
    Periprosthetic Joint Infection : General Aspects
    Periprosthetic Joint Infection after Total Hip and Knee Arthroplasty
    Periprosthetic Joint Infection after Shoulder Arthroplasty
    Periprosthetic Joint Infection after Elbow Arthroplasty
    Periprosthetic Joint Infection after Ankle Arthroplasty
    Osteomyelitis : Classification
    Osteomyelitis in Children
    Acute Osteomyelitis in Adults
    Subacute Osteomyelitis : Tuberculous and Brucellar Vertebral Osteomyelitis
    Chronic Osteomyelitis in Adults
    Diabetic Foot Osteomyelitis
    Osteomyelitis of the Jaws
    Fracture-related Infection of Long Bones
    Implant-Associated Vertebral Osteomyelitis
    Postoperative Sternal Osteomyelitis.
    Digital Access Wiley 2021
  • Article
    Schüssler P, Eisenburg J, Kruis W, Marget W.
    Fortschr Med. 1978 Nov 02;96(41):2059-63.
    Recent investigations of several authors on portal venous and systemic endotoxemia in healthy adults have shown that endotoxins absorbed from the intestinal mucosa are found in portal venous blood, cleared by the RES of the liver and usually cannot be determined in peripheral blood. In patients with liver disease, however, there was often a reduced endotoxin clearance with spillover of endotoxin resulting in systemic endotoxemia. Among the complications of systemic endotoxemia, hepatocytotoxicity, pyrogen reaction, disseminated intravascular coagulation, impaired renal function, and endotoxic shock are most hazardous. In addition, O-antibody titers and lipid-A-antibody titers were found to be higher in patients with liver disease and in patients with Crohn's disease than in control groups. The investigations indicate that intestinal endotoxins are of importance in the pathogenesis of liver disease and of Crohn's disease and that reduction of intestinal endotoxins by antibiotics may be of value in the therapy of these diseases.
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