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  • Book
    Anna Lembke, M.D.
    Summary: We are living in a time of unprecedented access to high-reward, high-dopamine stimuli: drugs, food, news, gambling, shopping, gaming, texting, sexting. The smartphone is the modern-day hypodermic needle, delivering digital dopamine 24/7 for a wired generation. Lembke explores new scientific discoveries that explain why the relentless pursuit of pleasure leads to pain-- and what to do about it. She illustrates how finding contentment and connectedness means keeping dopamine in check. The secret to finding balance is combining the science of desire with the wisdom of recovery. -- adapted from jacket

    Contents:
    Introduction: The problem
    The pursuit of pleasure. Our masturbation machines ; Running from pain ; The pleasure-pain balance
    Self-binding. Dopamine fasting ; Science, time, and meaning ; A broken balance?
    The pursuit of pain. Pressing on the pain side ; Radical honesty ; Prosocial shame
    Conclusion: Lessons of the balance.
    Print Unavailable: Checked out Recall Item
    Location
    Version
    Call Number
    Items
    Books: General Collection (Downstairs)
    2021
    BF515 .L46 2021
    1
  • Article
    Saito K.
    Nihon Yakurigaku Zasshi. 1978 May;74(4):427-40.
    Immunocytochemical techniques locating neurotransmitter-synthsizing enzymes are currently being employed to determine the nature of transmitters associated with individual neurons. The use of peroxidase-anti-peroxidase Fab (PAP Fab) complex modified from Sternberger's PAP method, among several other immunocytochemical methods is recommended for the visualization of antigens in cerebral tissues. The enzyme fixed in nervous tissues is reacted with anti-enzyme produced in rabbits followed by incubation with goat-anti-rabbit serum. Subsequent application of PAP Fab complex prepared separately results in a formation of a complex composed of enzyme: anti-enzyme: goat-anti-rabbits: PAP-Fab. The enzymes can be visualized under light and electron microscope by the deposition produced by the action of peroxidase on 3,3'-diaminobenzidine. Thus, the antibody to glutamate decarboxylase (GAD), the enzyme that synthesizes gamma-aminobutyric acid (GABA) was employed to identify GABAergic neurons in central nervous system of rodents. Specific staining for GAD was highly localized in close association with synaptic vesicles in certain axon terminals including basket, Golgi and the Purkinje cell terminals in the cerebellum. The distribution of GAD observed in immunocytochemical preparations was consistent with indirect biochemical, physiological and morphological data dealing with the synaptic role of GABA neurons in the cerebellum. The correlation of the immunocytochemical distribution of GABA neurons in the spinal cord, substantia nigra, olfactory bulb, retina and Ammon's horn with physiological and biochemical results can also been obtained. The method has been successfully employed to visualize dopamine-beta-hydroxylase (DBH) and substance P. DBH, as an indicative enzyme for noradrenergic (NA) neurons, was highly localized in the neuronal soma of the locus coeruleus and in synaptic varicosities in the stria terminalis associated with synaptic vesicles. Association of substance P in probable primary afferent terminals with large vesicles also supports the synaptic function of the compound in the spinal cord.
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