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- BookCurtis D. Klaassen and John B. Watkins, editors.Summary: This book describes the science of toxicology, and includes important concepts from anatomy, physiology, and biochemistry to facilitate the understanding of the principles and mechanisms of toxicant action on specific organ systems. A summary of key points at the beginning and review questions at the end of each chapter help you study, understand, and memorize the material.
Contents:
Unit 1: General principles of toxicology. History and scope of toxicology
Principles of toxicology
Mechanisms of toxicity
Risk assessment
Unit 2: Disposition of toxicants. Absorption, distribution, and excretion of toxicants
Biotransformation of xenobiotics
Toxicokinetics
Unit 3: Nonorgan-directed toxicity. Chemical carcinogenesis
Genetic toxicology
Developmental toxicology
Unit 4: Target organ toxicity. Toxic responses of the blood
Toxic responses of the immune system
Toxic responses of the liver
Toxic responses of the kidney
Toxic responses of the respiratory system
Toxic responses of the nervous system
Toxic responses of the ocular and visual system
Toxic responses of the heart and vascular system
Toxic responses of the skin
Toxic responses of the reproductive system
Toxic responses of the endocrine system
Unit 5: Toxic agents. Toxic effects of pesticides
Toxic effects of metals
Toxic effects of solvents and vapors
Toxic effects of radiation
Toxic effects of terrestrial animal
Toxic effects of plants, fungi, and algae
Unit 6: Environmental toxicology. Air pollution
Ecotoxicology
Unit 7: Applications of toxicology. Food toxicology
Analytic/forensic toxicology
Clinical toxicology
Occupational toxicology.Digital Access AccessPharmacy 2015 - ArticleHornych A.Contrib Nephrol. 1978;12:54-68.Prostaglandins A1, B1, E2, Falpha and PRA have been measured by radioimmunoassay in peripheral or renal venous blood of different groups of hypertensive and control subjects. PGA1 and PGE2 were significantly increased in renal, renovascular, labile and essential hypertension. PGFalpha was significantly increased only in patients with unilateral renal atrophy and in some patients with renovascular and essential hypertension. There was a significant positive correlation between PRA and PGA1 or B1, but not with PGE2 or Falpha. The increase of PGA and PGE represents a secondary antihypertensive, diuretic and natriuretic mechanism, the increase of PGF a direct hypertensive mechanism.