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  • Book
    editor, Mark C. Houston.
    Summary: "Personalized and Precision Integrative Cardiovascular Medicine embraces a systems-oriented medical approach that works to identify and understand the underlying or root causes of disease. It takes into account the personalization of healthcare as each patient is unique. It employs in-depth health history taking, scientific testing and environmental and lifestyle review. It is used as disease prevention and for the treatment of chronic conditions (such as heart disease) through nutrition, supplementation, life-style changes, and stress management. Integrative Medicine is a model of healthcare in which conventional Western medicine is integrated with non-conventional or alternative modalities. And Metabolic Medicine/Cardiology is a newer field of medicine which concentrates on the prevention, management and treatment of cardiovascular disease at the cellular level through biochemical interventions. All three of these complementary approaches to Cardiovascular Medicine will be covered in this new title"-- Provided by publisher
    Digital Access LWW Health Library 2020
  • Article
    Rajan KS, Jaw R, Grecz N.
    Bioinorg Chem. 1978 Jun;8(6):477-91.
    The possible relationship between the water binding by bacterial endospores and their dormancy and heat resistances has been examined in terms of the coordination characteristics of the spore-bound calcium. Stabilities of the calcium complexes of typical cytoplasmic and structural spore components were determined by potentiometric equilibrium pH measurements in model systems consisting of DPA, glycine, alanine, glutamic acid, alanyl-glutamic acid, triglycine, and tetraglycine. The Ca++-form and H+-form spores of Clostridium botulinum 33A were investigated in vivo with respect to their water sorption and heat-resistance characteristics. The results suggest that the complexing of calcium and Ca(II)-DPA may be biologically significant for spore resistance and dormancy at the following three levels: (1) complexing with spore cytoplasmic pool constituents consistent with the idea of a metal-chelate cross-linked cytoplasm or spore cement stabilizing the essential biological macromolecules, (2) complexing with structural components of the spore as indicated by the interaction with model peptides, and (3) coordination with water to produce an apparently dehydrated environment in the spore as evident from the much greater water-sorption capacity of the Ca++-form spores vs the much smaller water sorption of the H+-form spores. Interestingly enough, DPA itself, in the absence of metal ion, showed some interaction with di-, tri-, and tetrapeptides and a weak but detectable interaction with amino acids. Although the exact mode of the DPA-peptide interaction is not clear, it is attractive to speculate about its possible involvement in the control of spore dormancy and resistance.
    Digital Access Access Options
  • Journal
    Print kn. 1-13; 1950-1976.