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- ArticleEmödi G, Rufli T.Tex Rep Biol Med. 1977;35:511-5.The effect of human leukocyte interferon on varicella-zoster infections was compared in a placebo controlled study. Thirty-six patients were treated with interferon and 26 with placebo. In the interferon treated group the duration of pain was shortened, the development of crust formation was enhanced and the viral clearance from lesions was accelerated, compared with the control group.