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  • Book
    Akshay Anand, editor.
    Summary: This book is a comprehensive and timely compilation of strategy, methods, and implementation of a proof of concept modified quality module of Good Laboratory Practices (GLP). This text provides a historical overview of GLP and related standards of quality assurance practices in clinical testing laboratories as well as basic research settings. It specifically discusses the need and challenges in audit, documentation, and strategies for its implications in system-dependent productivity striving research laboratories. It also describes the importance of periodic training of study directors as well as the scholars for standardization in research processes. This book describes different documents required at various time points of a successful Ph.D and post-doc tenure along with faculty training besides entire lab establishments. Various other areas including academic social responsibility and quality assurance in the developing world, lab orientations, and communication, digitization in data accuracy, auditability and back traceability have also been discussed. This book will be a preferred source for principal investigators, research scholars, and industrial research centers globally.

    Contents:
    1 Historical Overview of Quality Assurance in Biological Research
    2 Conceptual framework of research data auditability
    3 Management of skilled human resources by Youth Oriented Good Laboratory Practices (YOG)
    4 Operationalization of research SOPs for PhD scholars
    5 Creating Data Recording Sheets (DRS) in quality management system
    6 The value of Master Schedules in benchmarking research productivity
    7 Logsheets and the Academic Progress of PhD Students
    8 Instigation and adherence to the quality assurance program to avoid academic conflicts
    9 Data fraud and essence of data verifiability
    10 The role of document control and archiving records in laboratory management
    11 Academic Social Responsibility and Quality Assurance in the developing world a framework for implementation
    12 Good Laboratory Practices: Lab orientations, meetings and value of communication
    13 Role of data digitization on data integrity.
    Digital Access Springer 2021
  • Article
    Gresser I.
    Tex Rep Biol Med. 1977;35:394-8.
    The effect of interferon in animals infected with some oncogenic viruses can be attributed to inhibition of viral replication or inhibition of the early events following viral infection. In those experimental systems in which continued administration of interferon proved effective after inoculation of oncogenic viruses, the effect may be due in part to an antiviral effect and in part to a direct action of interferon on the multiplication of precursor cells or tumor cells themselves. In animals bearing autochthonous tumors or grafted with transplantable tumors, the effects appear to be due in part to a a direct inhibition of the multiplication of the tumor cell (or an effect on the behavior of these tumor cells) and in part to an effect on the host - the nature of which remains to be defined. We must learn more of the interaction of interferon with host cells and understand how so many apparently different effects are triggered by this "polypractic substance" (6) before we can clarify the mechanism by which interferon can confer protection on animals infested with viruses, protozoa, or tumor cells.
    Digital Access Access Options