Today's Hours: 8:00am - 10:00pm
Lane Medical Library

Search

Filter Results

Did You Mean:

Search Results

Sort by
relevance
  • Book
    Shiyang Pan, Jinhai Tang, editors.
    Summary: This book covers the discovery of molecular biomarkers, the development of laboratory testing techniques and their clinical applications, focusing on basic research to clinical practice. It introduces new and crucial knowledge and ethics of clinical molecular diagnosis. This book emphasizes the applications of clinical molecular diagnostic test on health management, especially from different diseased organs. It lets readers to understand and realize precision healthcare.

    Contents:
    Intro
    Foreword
    Coordinators
    Preface
    Acknowledgments
    Contents
    About the Editors and Contributors
    About the Editors
    Editorial Board
    Contributors
    Part I: Principles of Clinical Molecular Diagnostics
    1: Molecules of Disease and Their Detection Methods
    1.1 Overview
    1.2 Molecular Mechanism of Diseases
    1.3 Nucleic Acid Detection Methods
    1.3.1 Nucleic Acid Amplification Technology
    1.3.2 Sequencing Technology
    1.3.3 Nucleic Acid Hybridization Technology
    1.3.4 Chip Technology
    1.3.5 Biosensing Technology
    1.4 Protein Detection Methods 1.4.1 Spectrum Technology
    1.4.2 Protein Chip Technology
    1.4.3 Labeled Immunoassay
    1.4.4 Mass Spectrometric Technique
    1.5 Future Trends
    References
    2: Assay Performance Evaluation
    2.1 Precision
    2.1.1 Terminology and Definitions
    2.1.2 Overview of the Precision Evaluation Process (Fig. 2.1)
    2.1.3 Features of the EP5-A2 Program
    2.1.4 EP5-A2 Experimental Protocol and Requirements
    2.1.4.1 Experimental Preparation
    Experimental Sample
    2.1.4.2 Experimental Method
    2.1.4.3 Quality Control
    2.1.5 Data Collection, Processing, and Statistical Analysis 2.1.5.1 Experimental Data Record
    2.1.5.2 Outlier Test
    2.1.5.3 Repeatability Estimate
    2.2 Accuracy
    2.2.1 Definitions
    2.2.2 Features of the EP9-A2 Program
    2.2.3 EP9-A2 Experimental Protocol and Requirements
    2.2.3.1 Experimental Preparation
    Sample Preparation
    Comparison Method Selection
    2.2.3.2 Experimental Method
    2.2.3.3 Quality Control
    2.2.4 Simple Accuracy Evaluation Plan
    2.2.4.1 Comparison of Patient Sample Results to Those of Another Procedure
    2.2.4.2 Method of Setting Reference Materials
    Sources of Reference Materials Procedure for Demonstration of Accuracy with Reference Materials
    2.3 Sensitivity
    2.3.1 Definitions
    2.3.2 Discussion of Several Common Terms
    2.3.3 Lower Limit of Linear Range (LLR), Biological Limit of Detection (BLD), and Functional Sensitivity (FS)
    2.3.3.1 Lower Limit of Linear Range (LLR)
    2.3.3.2 Biological Limit of Detection (BLD)
    2.3.3.3 Functional Sensitivity (FS)
    2.3.3.4 Experimental Precautions
    Blank Sample
    Detection Limit Sample
    Time Required for the Experiment
    2.3.4 Limits of Blank, Limits of Detection, and Limits of Quantitation 2.3.4.1 Overview
    2.3.4.2 General Method for Determining the Limits of Blank (LoB)
    2.4 Analytical Measurement Range
    2.4.1 Definitions
    2.4.2 EP6-A Protocol and Requirements
    2.4.2.1 Experimental Requirements
    Device Familiarization Period
    Duration of the Experiment
    Specimen of the Experiment
    Number of Samples
    Matrix Effects
    Selection of Materials Used to Supplement Samples
    Analyte Range
    Sample Preparation and Value Assignment
    2.4.2.2 Analytical Sequence
    2.4.2.3 Preliminary Data Check
    Outlier Inspection
    Determination of the Linear Range
    Digital Access Springer 2021
  • Article
    Kazmi SJ, Mitchell AG.
    J Pharm Sci. 1978 Sep;67(9):1260-6.
    Mathematical models were investigated for the distribution and antimicrobial activity of chlorocresol in solubilized and emulsified systems stabilized with a nonionic surfactant. The concentration of free preservative in the solubilized systems was described adequately by an equation widely used to describe the binding of small molecules to macromolecules. For the emulsions, this equation was combined with an expression for the partitioning of the preservative between the oil and water phases. It was confirmed that short-term antimicrobial activity can be related to the free (unbound) preservative concentration in the aqueous phase and that preservative solubilized within the surfactant micelles or partitioned into the oil phase does not contribute to short-term preservation.
    Digital Access Access Options