Search

Search Results

• Book

  Radiologic Physics : the Essentials

  Zhihua Qi, Robert D. Wissman.

  Digital Access Ovid 2020
  Get Shareable Link

  View Details
• Article

  Fetal hemoglobin in paroxysmal nocturnal hemoglobinuria (PNH): evidence for derivation of HbF-containing erythrocytes (F cells) from the PNH clone as well as from normal hemopoietic stem cell lines.

  Papayannopoulou T, Rosse W, Stamatoyannopoulos G.

  Blood. 1978 Oct;52(4):740-9.

  The cellular distribution of HbF was studied in nine patients with paroxysmal nocturnal hemoglobinuria (PNH) by measuring the level of HbF and determining the number of HbF-containing red cells (F cells) in whole blood and in the population of normal cells obtained after immune lysis of the abnormal erythrocytes. The amounts of HbF and the F cell frequencies found in the normal red cells were strikingly similar to the values seen in whole blood. The observed frequencies of F cells in normal cells best fitted those expected under the assumption that the F cells arise equally from normal hemopoietic stem cells and from the stem cells with the PNH defect. Since PNH appears to be a clonal hemopoietic stem cell disorder, this evidence argues against a derivation of F cells from distinct pluripotent stem cell lines.

  Digital Access Access Options
  Get Shareable Link

  PubMed