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  • Book
    Antoinette Maassen van den Brink, Paolo Martelletti, editors.
    Summary: Intended to promote a more appropriate and modern therapeutic approach to migraine management, this book is the first to deal with monoclonal antibodies in this context. Authored by the most respected migraine experts from around the globe and drawing on the lessons learned in both clinical trials and clinical practice, it reviews the current state of knowledge on this important therapeutic innovation, which has produced impressive data in randomized controlled trials, and the efficacy and safety of which have been confirmed in day-to-day real-world use. Given its scope, the book will appeal to a broad range of specialists, including pharmacologists, clinical pharmacologists, neurologists and internists, but also to residents and medical students.

    Contents:
    The CGRP family of neuropeptides and their receptors in the trigeminovascular system
    Pharmacology; where do the mAbs act, gepants vs mAbs
    Monoclonal Antibody Biology
    Guidelines for clinical trials
    Human Models
    CGRP Antibodies for Animal Models of Primary and Secondary Headache Disorders
    Galcanezumab
    Eptinezumab
    Erenumab
    Fremanezumab
    Potential side effects and pregnancy
    Real-world data, clinical practice so far
    Migraine vs Cluster headache and potential other indications.
    Digital Access Springer 2021
  • Article
    Fagraeus A, Tyrrell DL, Norberg R, Norrby E.
    Arch Virol. 1978;57(4):291-6.
    Fibroblasts growing on glass have microfilaments arranged in bundles. These can be demonstrated by indirect immunofluorescent technique using human antiactin serum or experimentally produced rabbit anti-actin serum. When monolayer cultures of epithelial cells and fibroblasts are infected with paramyxovirus, such as measles, mumps, Sendai and NDV, there is a striking decrease of the bundles. Rabies and adenoviruses do not seem to influence the staining of microfilaments. The microfilament decreasing effect in the cells correlates to the finding by SDS-polyacrylamide-gel-electrophoresis of actin within virions of the paramyxoviruses.
    Digital Access Access Options