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  • Book
    Carmen Molina-París, Grant Lythe, editors.
    Summary: The purpose of this book is to present current mathematical and computational models that are used to describe and characterise the immunology of T cells. The reader will be exposed to a variety of tools/methods that go hand-in-hand with the T cell-mediated immunological process that is being modelled. We aim in the proposed book to emphasise the role that mathematical (or computational) modelling has already played in Immunology. Each chapter will provide an example of the contribution of mathematics to T cell immunology under one of the following four headings: i) Generation of hypotheses, ii) Quantification of immunological processes, iii) Definition of observables to measure given an experimental objective, iv) reconciling disparate (or even conflicting) experimental results.

    Contents:
    Cytokine receptor signaling and CD4/CD8 lineage choice during T cell development in the thymus
    An agent-based model of T helper cell fate decisions in the thymus
    Modelling naive T cell homeostasis
    Mechanistic models of CD4 T cell homeostasis and reconstitution in health and disease
    Section 1MODELING THE DYNAMICS OF CD4+ T CELLS IN HIV- 1 INFECTION
    Modelling the response to Interleukin-7 therapy in HIV-infected patients
    Modeling immunopathology during persistent viral infections
    Delay in differentiation may suggest division of labour in models for CD8+ T cell differentiation
    Inferring differentiation order in adaptive immune responses from population level data
    Experimental and mathematical approaches to quantify recirculation kinetics of lymphocytes
    The public face and private lives of T cell receptor repertoires
    Population dynamics of immune repertoires
    Mathematical Modelling of T cell activation
    Agent-based model of heterogeneous T cell activation in vitro
    CTLA-4 mediated ligand trans-endocytosis: a stochastic model
    Automated gating and dimension reduction of high-dimensional cytometry data
    Index.
    Digital Access Springer 2021
  • Article
    Jensen JB, Trager W.
    Am J Trop Med Hyg. 1978 Jul;27(4):743-6.
    The establishment of new strains of Plasmodium falciparum in continuous culture is described. One line (FCR-2), isolated from an individual who had traveled extensively through South America, was passed initially through Aotus trivirgatus monkeys and then cultured into human erythrocytes using the flow-vial technique. A strain of P. falciparum FMG), shipped by air freight on wet ice from The Gambia, was cultured directly from a human infection into continuous culture using the Petri dish-candle jar technique, giving line FCR-3. Two other strains (6252 and FSG) were hand carried by a commercial flight on wet ice from the Gambia and were initiated into culture at the same time using the same media, sera, and erythrocytes. After 6 wk in vitro the 6252 strain became adapted as line FCR-4, whereas FSG had died out. Normal-looking gametocytes were seen in all four strains reported here. Notwithstanding their normal appearance they would not exflagellate in vitro, nor were they infective to Anopheles stephensi mosquitoes via membrane feeding. Production of new gametocytes continued for 6 mo, then gradually stopped.
    Digital Access Access Options