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  • Book
    J. Robin Harris, Jon Marles-Wright (editors).
    Summary: This book covers important topics such as the dynamic structure and function of the 26S proteasome, the DNA replication machine: structure and dynamic function and the structural organization and protein-protein interactions in the human adenovirus capsid, to mention but a few. The 18 chapters included here, written by experts in their specific field, are at the forefront of scientific knowledge. The impressive integration of structural data from X-ray crystallography with that from cryo-electron microscopy is apparent throughout the book. In addition, functional aspects are also given a high priority. Chapter 1 is available open access under a Creative Commons Attribution 4.0 International License vialink.springer.com.

    Contents:
    Chapter 1. Structure, Dynamics and Function of the 26S Proteasome
    Chapter 2. Factor VIII and Factor V Membrane Bound Complexes
    Chapter 3. An Overview of DPS: Dual Acting Nanovehicles in Prokaryotes with DNA Binding and Ferroxidation Properties
    Chapter 4. Structure and Function of the Separase-Securin Complex
    Chapter 5. The DNA Replication Machine: Structure and Dynamic Function
    Chapter 6. Recent Progress in Structural Studies on the GT-C Superfamily of Protein Glycosyltransferases
    Chapter 7. How Structures of Complement Complexes Guide Therapeutic Design
    Chapter 8. Architecture and Assembly of the Bacterial Flagellar Motor Complex
    Chapter 9. Cellulosomes: Highly Efficient Cellulolytic Complexes
    Chapter 10. Leucine Dehydrogenase: Structure and Thermostability
    Chapter 11. Structure, Function and Physiology of 5-Hydroxytryptamine Receptors Subtype 3
    Chapter 12. The SF3b Complex Is an Integral Component of the Spliceosome and Targeted by Natural Product-based Inhibitors
    Chapter 13. Interaction Networks of Ribosomal Expansion Segments in Kinetoplastids
    Chapter 14. Hepatitis B Core Protein Capsids
    Chapter 15. Fibrinogen and Fibrin
    Chapter 16. Structural Organization and Protein-protein Interactions in Human Adenovirus Capsid
    Chapter 17. A Structural Perspective on Gene Repression by Polycomb Repressive Complex 2
    Chapter 18. Assembly and Function of the Anthrax Toxin Protein Translocation Complex.
    Digital Access Springer 2021
  • Article
    Beschorner WE, Hutchins GM, Elfenbein GJ, Santos GW.
    Am J Pathol. 1978 Jul;92(1):173-86.
    The thymus glands from 11 patients with aplastic anemia or acute leukemia who received allogeneic bone marrow transplants were studied at autopsy. All showed marked cortical involution. In the short-term survivors the medulla and perivascular spaces were lymphocyte-depleted and the epithelial cells formed pseudorosettes. In those surviving over 2 months, increasing numbers of small lymphocytes were present, presumably reconstituted with donor lymphocytes. Phagocytosis of cellular debris was frequent, especially in patients with graft-versus-host reaction (GVHR) or treated with anithymocyte globulin (ATG). Plasma cells were numerous in perilobular tissue and were occasionally found within the medulla. The findings are compatible with the concept that the thymus plays an important role in the immune deficiency experienced after allogeneic bone marrow transplantation and in the subsequent lymphoid reconstitution.
    Digital Access Access Options