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  Management of obstructive sleep apnea : an evidence based, multidisciplinary textbook

  Ki Beom Kim, Reza Movahed, Raman K. Malhotra, Jeffrey J. Stanley, editors.

  Springer Nature eBook.

  Summary: This book provides comprehensive information on the etiology, pathophysiology, medical implications, diagnosis, and surgical and nonsurgical treatment of obstructive sleep apnea (OSA). Divided into five parts, the book begins with principles and fundamentals of OSA and its diagnostic considerations. Subsequent parts then address non-surgical management, surgical management, and maxillomandibular advancements for OSA. Chapters seek to approach this common disorder from the viewpoint of multiple specialties, thereby promoting the development of a broad strategy for the evaluation and management of OSA patients that draws on each of them. An invaluable reference, Management of Obstructive Sleep Apnea: An Evidence-Based, Multidisciplinary Textbook meets the needs of advanced dental and medical students, orthodontic, maxillofacial, ENT, neurology, and plastic surgery residents, and sleep medicine and pulmonary physicians.
  
  Contents:
  Principles and Fundamentals: Introduction
  Anatomical Aspects of Airway
  Classification of Sleep-Related Breathing Disorders
  Pathophysiology of OSA
  Pediatric Sleep-Related Breathing Disorders
  Health Consequences of OSA
  Psychological Effect of OSA. Diagnostic Considerations: Clinical Evaluation of OSA Patients
  Temporomandibular Evaluation
  Obesity and OSA
  Diagnostic Testing (Polysomnography And Home Sleep Apnea Testing)
  Airway Imaging
  Craniofacial Morphology Related to OSA
  Craniofacial Syndromes And Sleep-Related Breathing Disorders
  Biomarkers Associated with OSA
  Orthodontic Considerations for OSA Patients. Non-Surgical Management of the OSA Patient: Conservative Options for Management for OSA
  Positive Airway Therapy (CPAP, APAP And BPAP)
  Oral Appliance Therapy
  Emerging Therapies. Surgical Management of the OSA Patient: Surgical Considerations for OSA Patients
  Tonsillectomy and Adenoidectomy
  Nasal Surgery for OSA Patients
  Uvulopalatopharyngoplasty and Laser-Assisted Uvulopalatoplasty
  Transpalatal Advancement Pharyngoplasty
  Radiofrequency Ablation
  Tongue and Hyoid Procedures
  Hypoglossal Nerve Stimulation
  Maxillomandibular Advancement
  Computational Fluid Dynamics in OSA
  Orthognathic Surgical Considerations in OSA Patients
  Individualized Orthodontic Treatment and Surgical Plan for Patients with OSA.

  Digital Access Springer 2021
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• Article

  The expression of tetracycline resistance after insertion of foreign DNA fragments between the EcoRI and HindIII sites of the plasmid cloning vector pBR 322.

  Widera G, Gautier F, Lindenmaier W, Collins J.

  Mol Gen Genet. 1978 Jul 25;163(3):301-5.

  In vitro recombination techniques were used to construct hybrid plasmids between pBR 322 and different DNA fragments derived from pML 21 and the E. coli chromosome. Some of the resulting hybrid plasmids express the tetracycline resistance gene of pBR 322, depending on the DNA fragment which has been ligated into the HindIII-site of pBR 322. From these studies we could conclude the direction of transcription of the kanamycin resistance gene in plasmid pML 21 with respect to the SalI, SmaI, HincII, KpnI, EcoRI and HindIII restriction sites. The replacement of the small HindIII-EcoRI-fragment in pBR 322 by other DNA fragments from the E. coli chromosome and selection for tcr-phenotypes showed that this system may be very useful for screening and analysis of promotor-containing DNA fragments.

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  PubMed