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  • Book
    Debbie L. Humphries, Marilyn E. Scott, Sten H. Vermund, editors.
    Contents:
    Part I: The Foundations of the Nutrition-Infection Nexus
    Pathways Linking Nutritional Status and Infectious Disease: A Conceptional Framework
    Core Principles of Nutrition
    Primer on Immune Response and Interface with Malnutrition
    Part II: Types of Infectious Diseases and Influences of Nutrition
    Bacterial Infections and Nutrition: A Primer
    Viral Infections and Nutrition: Influenza Virus as a Case Study
    Nutrition and Protozoan Pathogens of Humans: A Primer
    Human Helminth Infections: A Primer
    Part III: Nutrition Issues During Major Infections: Case Studies of Nutrition and Infectious Disease
    Nutrition and Diarrheal Disease and Enteric Pathogens
    Nutrition in HIV and Tuberculosis
    Nutrition and Arboviruses
    Nutritional Frameworks in Malaria
    Soil-Transmitted Helminths: Does Nutrition Make a Difference?
    Part IV: Integration of Cross-Cutting Issues in Nutrition/Infection Interactions
    Drug-Nutrition Interactions in Infectious Diseases
    Co-infection and Nutrition: Integrating Ecological and Epidemiological Perspectives
    Nutrition and Infections in the Context of Global Environmental Change
    Public Health and Clinical Implications of Nutrition/Infection Interactions.
    Digital Access Springer 2021
  • Article
    Gelfand JA, Hurley DL, Fauci AS, Frank MM.
    J Infect Dis. 1978 Jul;138(1):9-16.
    The role of complement in experimental disseminated candidiasis was studied in normal guinea pigs, animals congenitally deficient in the fourth component of complement (C4), and animals depleted of alternative pathway activity by cobra venom factor (CVF). Animals pretreated with CVF and challenged with Candida albicans had a high rate of mortality. Results of quantitative organ cultures corroborated prior reports that the kidney was the major target organ of infection. Infection of the kidney was markedly enhanced by CVF-induced depletion of the alternative pathway but not by classical pathway deficiency (deficiency in C4). There were differences among organs (kidney, liver, and spleen) in their requirement for complement to mount an effective host defense response. Ultimately, the integrity of the alternative pathway and late components of complement appears necessary for the limitation of and survival from sepsis due to C. albicans in nonimmune animals.
    Digital Access Access Options