BookJamshid H. Karimov, Kiyotaka Fukamachi, Randall C. Starling, editors.
Springer Nature eBook.
Summary: This book provides a comprehensive overview of mechanical circulatory support of the failing heart in adults and children. The book uniquely combines engineering knowledge and the clinicians perspective into a single resource, while also providing insights into current and future development of mechanical circulatory support technology, such as ventricular assist devices, the total artificial heart and catheter-based technologies for heart failure. Topics featured in this book include: The history of mechanical circulatory device development. Fundamentals of hemodynamics support. Clinical management of mechanical circulatory devices. Surgical implantation techniques. Current limitations of device therapies in advanced heart failure. Advanced and novel devices in the development pipeline. Opportunities for advancement in the field. Mechanical Support for Heart Failure: Current Solutions and New Technologies is a must-have resource for not only physicians, residents, fellows, and medical students in cardiology and cardiac surgery, but also clinical and basic researchers in biomedical engineering with an interest in mechanical circulatory support, heart failure, and new technological applications in medicine.
Contents:
Intro
Foreword
Foreword
Preface
Contents
Contributors
Part I: Overview of the Mechanical Circulatory Support
1: A History of Mechanical Circulatory Support
The Possibility of Mechanical Circulatory Support Revealed
The US Artificial Heart Program as Key Catalyst
Early Assist Devices: 1960s-1970s
Early Total Artificial Hearts: 1950s-1960s
The Goal of Permanent Replacement: TAHs
Wider Clinical Uptake: VADs
Conclusion
References
2: A Personalized History of Rotary Blood Pumps
Epiphany
The Secret of my Success: Serendipity The Beginning of the Journey
Happy Chance
First Human Implantation of a Rotary Blood Pump: A Moment in History [13]
Patient Selection
Case Report
CorAide LVAD
HeatWare HVAD
Complete Magnetic Suspension
The Future
Stroke
Percutaneous Site Infection
Pump Intelligence
Lessons Learned
References
3: History of Pediatric Devices for Mechanical Circulatory Support
Introduction
Early History Leading to the Need for Pediatric Mechanical Circulatory Devices
Key Events Leading Up to Pediatric ECMO
Evolution of Pediatric Ventricular Assist Devices Conclusions
References
4: Overview of Mechanical Circulatory Support Devices and Concepts
Introduction
The Intra-aortic Balloon Pump (IABP)
The Impella Pump
TandemHeart
Extracorporeal Membrane Oxygenation (ECMO)
HeartMate III
References
5: Physiology of Blood Pump Circulation in Heart Failure
Introduction
Types of Ventricular Assist Device
Continuous-Flow Left Ventricular Assist Device (cf-LVAD) Hemodynamics
Pressure-Flow Relationship (HQ Curve)
Impact of LVAD Pumping on Ventricular Mechanics and Energetics
Physiology of Myocardial Energetics LVAD Impact on Ventricular Mechanics
Impact of Blood Inertia on the Instantaneous Pressure-Flow Relationship
Pump Power and Flow Relationship
Artificial Flow Pulsatility
Impact of RPMs on LVAD Flow and Total Flow to the Body
Ramp Test
HeartMate II Echocardiographic Ramp Test
HVAD Echocardiographic Ramp Test
Impact of RPM on Left Ventricle
Impact of RPM on Total Body Flow
Defining and Quantifying Ventricular Unloading
Impact of RPM on CVP and PCWP
Special Considerations
RV Failure with LVAD
Pulmonary Hypertension
Clinical LVAD Physiology
Hypertension VAD-Exercise Physiology
Hemodynamic Factors Affecting VAD Flow During Exercise
Chronotropic Incompetence and Preload
Effect of Pump Speed Adjustment During Exercise
Summary
References
6: Engineering Requirements for Mechanical Circulatory Support Devices
Introduction
Engineering MCS Devices
Differing MCS Designs and Their Corresponding Engineering Requirements
Risk Analysis to Engineer MCS Devices
Disclaimer
References
7: Clinical Requirements for Mechanical Circulatory Support Devices
Introduction
Long-Term MCS and End-Stage Heart Failure