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  • Book
    senior editors, Kathy N. Shaw, Richard G. Bachur ; associate editors, James M. Chamberlain, Jane Lavelle, Joshua Nagler, Joan E. Shook.
    Summary: "Our primary goal as practitioners is to provide high-quality, safe care for each child who arrives in our emergency department. The ability to stay current with knowledge and clinical skills across all possible conditions is impossible for any clinician. Furthermore, the evidence may be poor, inconsistent, or changing for the management of many diseases or injuries. This leads to a wide variation in practice, high rates of inappropriate care, patient harm, and wasted resources. Additionally, the model of optimal care in emergency departments is challenged by high acuity and crowding that demands teamwork, resources, a well-structured quality program, and a culture of high reliability. With this new edition of the Textbook of Pediatric Emergency Medicine, we provide easy web-based access for use in practice, links to clinical pathways based on the latest evidence and expert consensus, and a new, streamlined format that emphasizes the goals of quality care"-- Provided by publisher.
    Digital Access
    Provider
    Version
    Ovid
    2021
    LWW Health Library (Pediatrics)
    2020
    LWW Health Library (Emergency)
    2020
  • Article
    Parvinen LM, Söderström KO, Parvinen M.
    Exp Pathol (Jena). 1978;15(2):85-96.
    Male sterility belongs to the recently recognized complications of cancer chemotherapy and has an increasing importance. Therefore, more information about the mode of action of anticancer drugs on mammalian spermatogenesis is needed. We have developed a technique based on transillumination of living, freshly isolated unstained rat seminiferous tubules, where the cells specifically killed by the drugs are recognized as dull zones. Early stages of cell degeneration can be rapidly analyzed by phase contrast microscopy of living cells. Because the transillumination technique, in addition, permits an accurate recognition of the segments of the seminiferous epithelial wave, the cells representing various stages of the mitotic and meiotic cell cycles during spermatogenesis can be isolated in living state for morphological analysis. Vinblastine and vincristine cause an arrest of mitotic and meiotic divisions to metaphase followed by cell death, which was more rapid after vincristine administration. Both alkaloids had a slight damaging effect on the pachytene spermatocytes. Large doses of both drugs primarily affected the Sertoli cells by destroying their microtubules and mitochondria. Vincristine specifically damaged the acrosomic system and the cytoplasmic bridges of the young spermatids.
    Digital Access Access Options