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  Infectious diseases in the intensive care unit

  Manish Soneja, Puneet Khanna, editors.

  Summary: Infections in intensive care is a very broad topic, and this book provides concise yet comprehensive coverage. It focuses on the appropriate and judicious use of microbiological, radiological and point-of-care tests in diagnostic work-ups and evidence-based management protocols. Moreover, it offers essential information on the diagnosis and management of commonly encountered infections in the intensive care unit, making it a handy ready-reference manual for intensivists.
  
  Contents:
  -- Sepsis in Intensive Care Unit
  Severe Community Acquired Infections in Intensive Care Unit
  Tropical Infections in Intensive Care Unit
  Ventilator Associated Pneumonia
  Nosocomial Infections (except Ventilator Associated Pneumonia)
  Approach to Fungal Infections in Intensive Care Unit
  Viral Infections in Intensive Care Unit (except HIV)
  Tuberculosis in Intensive Care Unit
  Infections of the Nervous System in Intensive Care Unit
  Obstetrical and Gynecological-Related Infections in Intensive Care Unit
  Human Immunodeficency Virus in Intensive Care Unit
  Infections in Post-transplant Patients in Intensive Care Unit
  Paediatric Infections in Intensive Care Unit
  Microbiology Laboratory Diagnosis of Infection in Intensive Care Unit
  Principles of Antibiotic Therapy in Intensive Care Unit
  Management of Gram Negative Multi Drug Resistant Organisms in Intensive Care Unit
  Management of Methicillin-resistant Staphylococcus Aureus in Intensive Care Unit
  Antifungal Therapy in Intensive Care Unit
  Antimicrobial Prophylaxis in Intensive Care Unit
  Antibiotic Stewardship in Intensive Care Unit
  Principles of Infection Prevention and Control in Intensive Care Unit.

  Digital Access Springer 2020
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• Journal

  Li͡etopis na Bŭlgarskata akademii͡a na naukiti͡e.

  Digital Access Full text via HathiTrust, 1-11, 1899/1900-1910; [h.c.] 1-22, 1911-1938/39.
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• Article

  Activation of radiosensitizers by hypoxic cells.

  Olive PL, Durand RE.

  Br J Cancer Suppl. 1978 Jun;3:124-8.

  Hypoxic cells can metabolize nitroheterocyclic compounds to produce toxic intermediates capable of affecting the survival of neighbouring oxygenated cells. Mutagenesis experiments with E. coli WP-2 343 (deficient in nitroreductase) indicated that reduction of nitroheterocyclics outside bacteria causes killing and mutations within bacteria, presumably due to the transfer of the "active" specie (s). Using animal tissue slices to reduce nitrofurans, cultured L-929 cells incubated under aerobic conditions were far more sensitive to the toxic and DNA damaging effects of these drugs. Transfer of the active species also occurs in a tissue-like environment in multicell spheroids where the presence of a hypoxic central core served to convert the nitroheterocyclics to intermediates which also damaged the neighbouring oxygenated cells.

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  PubMed