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  • Book
    Christoph W. Michalski, Jonas Rosendahl, Patrick Michl, Jörg Kleeff, editors.
    Summary: This book incorporates a multi-disciplinary approach to present how research results can be translated into clinical trials. The first part begins with a chapter on variants of pancreatic cancer, precursor lesions and groups of people at risk to developing the disease. There is a particular focus on intraductal papillary mucinous neoplasia as a large-scale clinical challenge in pancreatology. The next two parts focus on diagnosis, biomarkers and stratification that emphasize how various approaches to biomarker development are important as both prognostic and predictive tools. The final part consists of personalized treatment approaches that include preclinical models of pancreatic cancer and stromal, epigenetic and metabolism targeting as promising approaches to be translated into early phase clinical trials. Chapters within this part also deal with approaches that are close to being implemented in clinical practice or are already being tested in (early) clinical trials, such as those that targeting the immune systems and strategies to overcome immunotherapy resistance; phase 1 clinical trials and translational approaches in surgical treatment. Written by experts in their fields, Translational Pancreatic Cancer Research provides an outlook towards future directions by integrating information both from basic and clinical research and though demonstrating pathways to better understanding pancreatic cancer and current approaches to translating these into clinical practice.

    Contents:
    Subtypes of Pancreatic Adenocarcinoma
    Surveillance and Intervention in IPMN
    Novel Biomarkers of Invasive IPMN
    Challenges and Opportunities for Early Pancreatic Cancer Detection: Role for protein biomarkers
    Metabolic Biomarkers of Pancreatic Cancer
    Blood-Based Circulating RNAs as Preventive, Diagnostic, Prognostic and Drugable Biomarkers for Pancreatic Ductal Adenocarcinoma
    Circulating tumor DNA as a novel biomarker for pancreatic cancer
    PDAC Subtypes/Stratification
    Circulating Tumor Cells as Biomarkers in Pancreatic Cancer
    Personalized Models of Human PDAC
    Therapeutic Targeting of Stromal Components
    Epigenetic Targeting
    Targeting Metabolism
    Targeting the Immune System in Pancreatic Cancer
    Phase I Trials in Pancreatic Cancer
    Translational Approaches in Surgical Treatment.
    Digital Access Springer 2020
  • Article
    Kondo H.
    Arch Histol Jpn. 1977;40 Suppl:221-30.
    Recent serial ultrathin section studies have shown that a single kind of nerve fiber innervates chief cells of the carotid body through various types of endings. These nerve endings have been described in previous papers as being vesicle-rich, mitochondria-rich or small and large calyciform; these endings occurred in en passant and bouton forms. The intracranial section experiments of the glossopharyngeal nerve seem to support the view that the nerve fiber innervating chief cells is sensory, the soma of which is located in the inferior (petrosal) ganglion, although conflicting data still exist. Two types of synapses have been found at the sites of apposition between nerve fibers and chief cells: one, named efferent or type 1 synapse, in which chief cells are postsynaptic; the other, named afferent or type 2 synapse, in which chief cells are presynaptic. The serial ultrathin section study has shown that a single nerve fiber forms both types, with the latter type predominating. The possibility is strongly suggested that most of efferent synapses on the chief cells are formed by sensory fibers which form numerous afferent synapses, but not by proper efferent fibers. The similarity between chief cells and SIF cells in the autonomic ganglia is suggested in terms of synaptic relations with neuronal elements.
    Digital Access Access Options