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  • Book
    Trisha Greenhalgh.
    Summary: This book addresses the common criticisms of evidence-based healthcare, dispelling many of its myths and misconceptions, while providing a pragmatic framework for testing the validity of healthcare literature. It also helps readers to understand the central principles of evidence-based medicine, critically evaluate published data, and implement the results in practical settings. The readers are guided through each fundamental step of inquiry, from searching the literature, to assessing methodological quality, and appraising statistics. -- Publisher description

    Contents:
    Why read papers at all?
    Searching the literature
    Getting your bearings : what is this paper about?
    Assessing methodological quality
    Statistics for the non-statistician
    Papers that report trials of drugs and other simple interventions
    Papers that report trials of complex interventions
    Papers that report diagnostic or screening tests
    Papers that summarise other papers (systematic reviews and meta-analyses)
    Papers that tell you what to do (guidelines)
    Papers that tell you what things cost (economic analyses)
    Papers that go beyond numbers (qualitative research)
    Papers that report questionnaire research
    Papers that report quality improvement case studies
    Papers that describe genetic association studies
    Applying evidence with patients
    Criticisms of evidence-based healthcare.
    Digital Access R2Library 2019
    Limited to 1 simultaneous user
  • Article
    Rajewsky K, von Hesberg G, Lemke H, Hämmerling GJ.
    Ann Immunol (Paris). 1978 Feb-Mar;129(2-3):389-400.
    Thirteen hybrid cell lines originating from the fusion of a BALB/c myeloma with strain A spleen cells were isolated each of which secreted an antibody with specificity for the carbohydrate of group A streptococci. The cell lines were stable over many in vivo passages in (BALB/c X A/J)F1 mice and secreted large amounts of antibodies into the serum and ascitic fluid of their hosts. Seven of the hybrid cell antibodies belonged to the IgM class, five were typed as IgG2a and one as an IgA immunoglobulin.
    Digital Access Access Options