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  Lynch syndrome : molecular mechanism and current clinical practice

  Naohiro Tomita, editor.

  Summary: This book offers a comprehensive review of Lynch Syndrome (LS), addressing both the basic and clinical aspects of this condition. Due to the recent advances in our understanding of the genetic mechanism of LS, and to new screening methods, including universal screening and/or multi-gene panel analysis, the standard treatment strategy for patients and family members of LS have been steadily improving. In this book, experts describe the diseases manifestations, discuss state-of-the-art diagnosis and management options, and offer a cutting-edge overview of the genetic and epigenetic basis of the syndrome. Providing essential insights into this new phase in the management of LS, this book is a valuable resource not only for colorectal surgeons, but also for general gastrointestinal clinicians, gynecologists, oncologists and all basic researchers with an interest in LS.
  
  Contents:
  1 Molecular mechanism of Lynch syndrome
  2 Clinical features of Lynch syndrome
  3 Pathology of Lynch syndrome-associated tumors
  4 Immunohistochemistry for mismatch repair proteins
  5 Genetic analysis for Lynch syndrome
  6 Lynch syndrome-associated gynecological malignancies
  7 Lynch syndrome-associated urological malignancies
  8 Screening for Lynch syndrome
  9 Surveillance Colonoscopy for Lynch Syndrome Patients
  10 Surgical approach for colorectal cancer in patients with Lynch syndrome
  11 Immunotherapy for Lynch syndrome patients
  12 Chemoprevention for Lynch syndrome-associated malignancies
  13 International collaboration for Lynch syndrome.

  Digital Access Springer 2020
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• Article

  An appraisal of tests for native DNA antibodies in connective tissue diseases. Clinical usefulness of Crithidia luciliae assay.

  Chubick A, Sontheimer RD, Gilliam JN, Ziff M.

  Ann Intern Med. 1978 Aug;89(2):186-92.

  Antibody to native DNA was measured by five techniques: the Crithidia luciliae immunofluorescence (CL-IF) test; filter radioimmunoassays using either untreated human KB DNA, endonuclease-treated KB DNA, or a synthetic polynucleotide (poly dAT); and the Farr immunoprecipitation assay using KB DNA. The specificity and sensitivity of the CL-IF assay was similar to that of the filter radioimmunoassay procedures using KB DNA. The CL-IF test showed an increased frequency of positive tests in patients with active disease and severe renal involvement. In patients with severe renal involvement, high titers of serum nDNA antibodies were measured by this procedure. A unique advantage of the CL-IF test was its ability to identify complement-fixing nDNA antibody. The presence of such antibody was correlated with high antibody titer and the presence of severe renal disease. The CL-IF assay is a simple and useful procedure for measurement of anti-nDNA.

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  PubMed