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- Bookedited by Deepak M. Kamat, Melissa Frei-Jones.Summary: This book provides a comprehensive overview of benign hematologic disorders in children. Divided into nine sections, the text reviews common hematologic disorders or conditions that affect children, while providing state-of-the-art information on pathophysiology, diagnosis, treatment, and management strategies. The text begins with a section on hematopoiesis, and the next section covers red blood cell disorders. The following sections provide overviews of platelet disorders, white blood cell disorders, and coagulation disorders. The sixth and seventh sections discuss neonatal hematology and bone marrow failure syndrome. The eighth section reviews supportive care, while the final section covers miscellaneous subjects including pediatric vascular anomalies and complement dysregulation syndromes. Written by experts in the field, Benign Hematologic Disorders in Children: A Clinical Guide is a valuable resource for clinicians and practitioners who treat children afflicted with these disorders.
Contents:
Part I: Origin of Blood Cells
Hematopoiesis
Part II: Red Blood Cell Disorders
Nutritional Anemias: Iron Deficiency and Megaloblastic Anemia
Lead Poisoning
Immune and Non-Immune Hemolytic Anemia
Sickle Cell Disease
Thalassemia
Disorders of RBC Metabolism
Red blood cell membrane defects
Part III: Platelet disorders
Immune Thrombocytopenia
Inherited and Congenital Thrombocytopenia
Platelet Disorders
Thrombocytosis in Children
Part IV: WBC disorders
Neutropenia
Granulocytosis
Disorders of Granulocyte Functions
Part V: Coagulation Disorders
Von Willebrand Disease
Hemophilia
Acquired Disorders of Coagulation in Neonates and Children
Thromboembolism
Heavy Menstrual Bleeding and Bleeding Disorders in Adolescents: A Primer for the Primary Care Physician
Part VI: Neonatal Hematology
Newborn Screening for Hemoglobinopathies
Neonatal Immune Hemolytic Anemia
Neonatal Hemostasis Disorders of Bilirubin Metabolism
Part VII: Bone Marrow Failure Syndrome
Failure of Erythrocyte Production
Inherited Bone Marrow Failure Syndromes
What Pediatricians Need to Know about Acquired Aplastic Anemia
Part VIII: Supportive Care
Immunizations in the Child with Sickle Cell Disease
Transfusion Medicine for Pediatrics
Management of infections in neutropenic patients
Part IX: Miscellaneous
Pediatric Vascular Anomalies: Opportunities in Primary Care
Complement Dysregulation Syndromes in Children and Adolescents. - ArticleArnow PM, Andersen RL, Mainous PD, Smith EJ.Am Rev Respir Dis. 1978 Jul;118(1):49-53.During a 4-week period, Aspergillus fumigatus caused disease in 2 patients and colonized a third patient in a renal transplant ward. Our investigation indicated that increased exposure of these patients to spores probably occurred during renovation of the ward one floor above it. Cases were significantly clustered (P = 0.014) during the period when work overhead caused dust to filter down through pores in the acoustical tiles of the false ceiling of the renal transplant ward. Swab cultures demonstrated A. fumigatus in the dust, and air samples showed heavy contamination with A. fumigatus and other fungi at and below a renovation site, but not on 2 distant wards. We concluded that dust can be an important source of aspergilli and that release of dust and spores during activities such as renovation may increase the risk of nosocomial Aspergillus infection in exposed, immunosuppressed patients.