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  • Book
    Giuliano Mariani, Sergi Vidal-Sicart, Renato A. Valdés Olmos, editors.
    Summary: The main goal of the second edition of this book is to update the content on the rapidly growing field of lymphoscintigraphy, a radionuclide-based imaging procedure that provides information on the functional status of the lymphatic system. Although the technique was originally introduced to identify the cause of peripheral edema (i.e., blockage of the venous or lymphatic circulation), more recent and widespread applications include radioguided biopsy of the sentinel lymph node in patients with solid cancers. This procedure is crucial for the adequate planning of oncologic surgery in a growing number of cancers, most notably breast cancer, cutaneous melanoma, head and neck cancers, penile cancer, and cervical cancer. The book focuses on the latest advances in lymphoscintigraphy techniques, including both novel tracers recently approved for clinical use (especially in the field of sentinel lymph node mapping) and the expanding role of hybrid imaging with SPECT/CT - and in sentinel node detection using hybrid tracers (radiolabeled and fluorescent) for dual-signature guidance. Each chapter addresses the clinical application of lymphoscintigraphy in different anatomic areas or disease conditions. After an introductory section concerning the pathophysiology of the specific site/disease, the clinical relevance and impact of lymphoscintigraphy is demonstrated by a collection of richly illustrated teaching cases describing the lymphoscintigraphic patterns most commonly observed, as well as anatomic variants and technical pitfalls. Emphasis is placed on tomographic multimodality imaging. The book gathers contributions by experts in nuclear oncology, who have revised their chapters by updating the didactic material and adding clinical cases. Regarding sentinel lymph node biopsy in particular, a major distinction of this text is the incorporation of the staging guidelines of the American Joint Committee on Cancer (8th edition) into the didactic material.

    Contents:
    Anatomy and physiology of lymphatic circulation
    Pathophysiology of lymphatic circulation in different disease conditions
    Methodological aspects of lymphoscintigraphy: radiopharmaceuticals and instrumentation
    Methodological aspects of lymphoscintigraphy: bicompartmental versus monocompartmental
    Lymphoscintigraphy for the differential diagnosis of peripheral edema and intracavitary lymph effusion
    The sentinel lymph node concept in oncologic surgery
    General concepts on radioguided sentinel lymph node biopsy: preoperative imaging, intraoperative gamma-probe guidance, intraoperative imaging, multimodality imaging
    SPECT/CT image generation and criteria of interpretation for sentinel lymph node mapping
    Preoperative and intraoperative lymphatic mapping for radioguided sentinel node biopsy in breast cancer
    Preoperative and intraoperative lymphatic mapping for radioguided sentinel node biopsy in cutaneous melanoma
    Preoperative and intraoperative lymphatic mapping for radioguided sentinel node biopsy in head and neck cancers
    Preoperative and intraoperative lymphatic mapping for radioguided sentinel node biopsy in non-small-cell lung cancer
    Preoperative and intraoperative lymphatic mapping for radioguided sentinel node biopsy in cancers of the gastrointestinal tract
    Preoperative and intraoperative lymphatic mapping for radioguided sentinel node biopsy in cancers of the female reproductive system
    Preoperative and intraoperative lymphatic mapping for radioguided sentinel node biopsy in cancers of the male reproductive system
    Preoperative and intraoperative lymphatic mapping for radioguided sentinel node biopsy in kidney and bladder cancers.
    Digital Access Springer 2020
  • Article
    Grove DI, Davis RS.
    Am J Trop Med Hyg. 1978 May;27(3):508-13.
    A study was undertaken to define the sensitivity and specificity of serological tests in bancroftian and malayan filariasis and correlate the findings with clinical disease. Sera were collected from subjects on three different islands in the Philippines: one endemic for bancroftian filariasis, another endemic for malayan filariasis and the third without endemic filariasis. Antibodies were measured, using rugia malayi as the source of antigen. Antibodies against adult worms measured by indirect immunofluorescence were found at a titer of 1:8 or greater in all patients with bancroftian or malayan filariasis but not in the control subjects. There was no relationship of antibody titer to clinical status. Antibodies against microfilariae were measured by indirect immunofluorescence and microfilarial agglutination. A high correlation was observed between the two methods. These antibodies were found in only one quarter, approximately, of patients with filariasis. Microfilarial antibodies were found more commonly in those patients with chronic lymphatic obstruction. It is concluded that measurement of antibodies to adult worms is a useful indicator of infection while microfilarial antibodies are correlated with disease.
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