Live Chat
Today's Hours: 10:00am - 6:00pm
Lane Medical Library

Search

Filter Results

Did You Mean:

Search Results

Sort by
relevance
  • Book
    Henning Willers, Iris Eke, editors.
    Summary: Molecular Targeted Radiosensitizers: Opportunities and Challenges provides the reader with a comprehensive review of key pre-clinical research components required to identify effective radiosensitizing drugs. The book features discussions on the mechanisms and markers of clinical radioresistance, pre-clinical screening of targeted radiosensitizers, 3D radiation biology for studying radiosensitizers, in vivo determinations of local tumor control, genetically engineered mouse models for studying radiosensitizers, targeting the DNA damage response for radiosensitization, targeting tumor metabolism to overcome radioresistance, radiosensitizers in the era of immuno-oncology, and more. Additionally, the book features discussions on high-throughput drug screening, predictive biomarkers, pre-clinical tumor models, and the influence of the tumor microenvironment and the immune system, with a specific focus on the challenges radiation oncologists and medical oncologists currently face in testing radiosensitizers in human cancers. Edited by two acclaimed experts in radiation biology and radiosensitizers, with thirteen chapters contributed by experts, this new volume presents an in-depth look at current developments within a rapidly moving field, with a look at where the field will be heading and providing comprehensive insight into the framework of targeted radiosensitzer development. Essential reading for investigators in cancer research and radiation biology.

    Contents:
    Introduction to Molecular Targeted Radiosensitizers: Opportunities and Challenges
    Translating Targeted Radiosensitizers into the Clinic
    Cartography of the Radiogenome of Human Cancers
    Mechanisms and Markers of Clinical Radioresistance
    Preclinical Strategies for Testing of Targeted Radiosensitizers
    3D Radiation Biology for Identifying Radiosensitizers
    Preclinical in vivo evaluation of novel radiosensitizers by local tumor control experiments
    Genetically Engineered Mouse Models for Studying Radiation Biology and Radiosensitizers
    Targeting the DNA Damage Response for Radiosensitization
    Targeting Tumor Metabolism to Overcome Radioresistance.-Targeting Tumor Hypoxia
    Normalizing the Tumor Microenvironment for Radiosensitization
    Radiosensitizers in the Era of Immuno-Oncology
    Index.
    Digital Access Springer 2020
  • Article
    Holland DR, Armstrong WM, Steinberg MI.
    Am J Physiol. 1978 Jul;235(1):C13-9.
    The Ca2+ ionophore A23187 (10(-6) to 3 X 10(-5) M) increased the force of contraction is isolated guinea pig atria. In individual twitches, peak tension, maximum rate of tension development, time to peak tension, and total twitch duration were all increased by A23187. Tripelennamine, indomethacin, and atropine did not significantly alter the inotropic effect of A23187. Serotonin produced changes in individual twitches that differed qualitatively and quantitatively from those of A23187. Therefore, the inotropic action of A23187 is probably not mediated by release of endogenous histamine, prostaglandins, acetylcholine, or serotonin. 45Ca influx and efflux were increased by A23187. The enhanced 45Ca efflux exceeded that which would be predicted if the ionophore acted only to increase the passive Ca2+ permeability of the myocardial cell membrane. These results suggest that A23187 facilitates the entry of extracellular Ca2+ into the myocardial cell and the release of intracellular Ca2+ stores into the myoplasm. The resultant increase in intracellular Ca2+ activity could account for the positive inotropic action of A23187.
    Digital Access Access Options