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  • Book
    John M. Hutson, Sonia R. Grover, Michele A. O'Connell, Aurore Bouty, Chloe A. Hanna, editors.
    Summary: This book covers advances in the molecular biology and embryology of sex development, describing each disorder in detail. Clinical presentation and diagnostic approach are described for babies and for those presenting later in childhood or at adolescence.

    Contents:
    Intro
    Preface for the Second Edition
    Acknowledgements for the Second Edition
    Contents
    About the Editors
    1: Introduction: Changing Landscapes
    1.1 Background
    1.1.1 Terminology
    1.1.2 Recent History of DSD
    1.1.3 Clinical Definition of DSD
    1.1.4 Incidence of DSD
    1.1.5 Clinical Care: Historical Perspective and Changes Over Time
    1.1.6 Human Rights and DSD: Where to from Here?
    References
    2: The Molecular Basis of Sex Determination and Differentiation: Implications for Understanding DSD
    2.1 Formation of the Bi-potential Gonad 2.10 Genetics and DSD
    2.11 Conclusion
    References
    3: Embryology of the Human Genital Tract
    3.1 The Urogenital Ridge
    3.1.1 Wolffian and Müllerian Duct Development
    3.2 Sexual Differentiation
    3.2.1 Testosterone
    3.2.2 Anti-Müllerian Hormone (AMH or MIS)
    3.2.3 Insulin-Like Hormone (INSL3)
    3.3 External Genitalia
    3.4 Gonadal Descent
    References
    4: Hormones Regulating Sex Development
    4.1 Introduction
    4.2 Testicular Hormones
    4.2.1 Testosterone Synthesis
    4.2.2 Androgen Receptor
    4.2.3 Control of Testosterone Levels 4.2.4 Anti-Müllerian Hormone (AMH)
    4.2.5 Insulin-Like Hormone 3 (INSL3)
    4.3 Ovarian Hormones
    4.4 The Placenta
    4.5 The Foetal Hypothalamic-Pituitary Axis
    4.6 Postnatal Hormone Levels and Implications (Fig. 4.4)
    References
    5: Embryology in DSD
    5.1 Sex Determination
    5.2 46,XY Complete Gonadal Dysgenesis
    5.3 Incomplete Testicular Differentiation (and Mixed Gonadal Dysgenesis)
    5.4 Anatomy of Caudal Internal Ducts in DSD
    5.5 Placental Failure
    5.6 Failure of the Hypothalamic-Pituitary-Gonadal Axis
    5.7 Failure of Hormone Action
    5.7.1 INSL3 5.7.2 AMH
    5.7.3 Androgen
    5.8 Morphogenesis of the Genitalia (See Also Chap. 9)
    5.9 Internal Genital Tract
    5.9.1 Wolffian Ducts
    5.9.1.1 In the Female
    5.9.1.2 In the Male
    Epididymis
    Vas Deferens
    Seminal Vesicles (SV)
    Cysts
    Agenesis and Hypoplasia
    5.9.2 Müllerian Ducts
    5.9.2.1 In the Female
    Anomalies of Development
    Aplasia and Hypoplasia
    Unicornuate Uterus
    Anomalies of Fusion
    Uterus Didelphys
    Bicornuate Uterus
    Anomalies of Septal Reabsorption
    Septate Uterus
    Arcuate Uterus
    5.9.2.2 In the male
    5.10 External Genitalia
    Digital Access Springer 2020
  • Article
    Welch JS, Dobson C.
    Trans R Soc Trop Med Hyg. 1978;72(3):282-8.
    Three immunofluorescent antibody assays were developed during this study: the direct (DFAT) and indirect (IFAT) fluorescent antibody tests using frozen worm sections, and the cyanogen bromide indirect fluorescent antibody test (CNBr-IFAT) using helminth antigens purified by affinity chromatography bound on to commercially prepared CNBr-Sepharose 4B beads. Purified antigens used in the CNBr-IFAT gave greater specificity and sensitivity than either the DFAT or IFAT. Dirofilaria immitis, Toxocara canis, Angiostrongylus cantonensis and Ascaris lumbricoides infections were studied in natural and zoonotic hosts and in rabbits immunized with antigens prepared from these parasites. In addition, a serological survey of Aboriginal Australians from Queensland was made.
    Digital Access Access Options