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  • Book
    Anton Bespalov, Martin C. Michel, Thomas Steckler, editors.
    Summary: This open access book, published under a CC BY 4.0 license in the Pubmed indexed book series Handbook of Experimental Pharmacology, provides up-to-date information on best practice to improve experimental design and quality of research in non-clinical pharmacology and biomedicine.

    Contents:
    1. Quality in Non-GxP Research Environment
    2. Guidelines & Initiatives for Good Research Practice
    3. Learning from principles of evidence-based medicine to optimize nonclinical research practices
    4. General Principles of Preclinical Study Design
    5. Resolving the tension between exploration and confirmation in preclinical biomedical research
    6. Blinding and Randomization
    7. Out of control? Managing baseline variability in experimental studies with control groups
    8. Quality of Research Tools
    9. Genetic background and sex: impact on generalizability of research findings in pharmacology studies
    10. Building robustness intro translational research
    11. Minimum information and quality standards for conducting, reporting, and organizing in vitro research
    12. Minimum Information in In Vivo Research
    13. A reckless guide to P-values: Local evidence, global errors
    14. Electronic Lab Notebooks and Experimental Design Assistants
    15. Data storage
    16. Design of meta-analysis studies
    17. Publishers' responsibilities in promoting data quality and reproducibility
    18. Quality governance in biomedical research
    19. Good Research Practice
    Lessons from Animal Care & Use
    20. Research collaborations and quality in research: foes or friends?
    21. Costs of implementing quality in research practice.
    Digital Access Springer 2020
  • Article
    Damian E, Ianăş O, Bădescu I, Oprescu M.
    Endocrinologie. 1978 Apr-Jun;16(2):97-9.
    The antisteroid urinary substance was checked out for its effect on LH and FSH under endogenous (castrated animal) and exogenous (administration of releasing hormone-GnRH) stimulation of the rat hypophysis. Administration of this substance partly blocked the castration induced LH and FSH serum increase by 65% and 37% respectively (p less than 0.01) and inhibited the GnRH stimulating effect depressing serum LH by 50% and FSH by 33% (p less than 0.05). In both experiments the LH and FSH content of the hypophysis was not influenced.
    Digital Access Access Options