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  • Book
    Guenther Witzany, editor.
    Summary: This is the first book to systemize all levels of communicative behavior of phages. Phages represent the most diverse inhabitants on this planet. Until today they are completely underestimated in their number, skills and competences and still remain the dark matter of biology. Phages have serious effects on global energy and nutrient cycles. Phages actively compete for host. They can distinguish between 'self and 'non-self (complement same, preclude others). They process and evaluate available information and then modify their behaviour accordingly. These diverse competences show us that this capacity to evaluate information is possible owing to communication processes within phages (intra-organismic), between the same, related and different phage species (interorganismic), and between phages and non-phage organisms (transorganismic). This is crucial in coordinating infection strategies (lytic vs. lysogenic) and recombination in phage genomes. In 22 chapters, expert contributors review current research into the varying forms of phage biocommunication and Phagetherapy. Biocommunication of Phages aims to assess the current state of research, to orient further investigations on how phages communicate with each other to coordinate their behavioral patterns, and to inspire further investigation of the role of non-phage viruses (non-lytic, non-prokaryotic) in these highly dynamic interactional networks.

    Contents:
    Chapter 1. What Does Communication of Phages Mean?
    Chapter 2. Phage-Phage, Phage-Bacteria, and Phage-Environment Communication
    Chapter 3. Phage communication and the ecological implications on microbial interactions, diversity, and function
    Chapter 4. Phage-Phage Interactions
    Chapter 5. Social interactions among bacteriophages
    Chapter 6. Phage protein interactions in the inhibition mechanism of bacterial cell
    Chapter 7. Are phages parasites or symbionts of bacteria?
    Chapter 8. Microbial communication networks: sketching a methodology to analyze communication involving bacteriophages inside environmental communities
    Chapter 9. Information stored in a phage particle: Lactobacillus delbrueckii bacteriophage LL-H as a case
    Chapter 10. Archaeal viruses and their interactions with CRISPR-Cas systems
    Chapter 11. Filamentous phages affect virulence of the phytopathogen Ralstonia solanacearum
    Chapter 12. Intra-population interactions and the evolution of RNA phages
    Chapter 13. ssRNA phages: life cycle, structure and applications
    Chapter 14. Phages as therapy or "dietary supplements"against multiresistant bacteria?
    Chapter 15. Bacteriophage application and biological safety (or how should I train my dog not to bite me)
    Chapter 16. Phage therapy: an alternative to antibiotics
    Chapter 17. Bacteriophage as a therapeutic agent to combat bacterial infection: A journey from history to application
    Chapter 18. Phagetherapy: Clinical applications
    Critical appraisal of randomized controlled trials
    Chapter 19. Bacteriophage therapies targets multiple diseases caused by protein misfolding
    Chapter 20
    Phage Therapy in Cystic Fibrosis. Challenges and Perspectives
    Chapter 21. Bacteriophage Applications for Food Safety
    Chapter 22. Bacteriophages for environmental applications: Effect of trans-organismic communication on wastewater treatments.
    Digital Access Springer 2020
  • Article
    Cami B, Kourilsky P.
    Nucleic Acids Res. 1978 Jul;5(7):2381-90.
    We have developped in situ methods of colony hybridization in which there is no need to replicate colonies one by one prior to hybridization. The best method consists in promoting partial lysis of the colonies on the plates by means of a resident thermoinducible prophage. It appears that colonies are heterogeneous with respect to prophage induction, so that survivors remain in each colony. Blotting onto nitrocellulose filters and hybridization with a highly radioactive probe permits the screening of many thousands of colonies per plate for the presence of a DNA sequence carried by a plasmid and complementary to the probe. This procedure greatly facilitates the isolation of recombinant plasmids which carry a specific DNA sequence. We also describe a second, less efficient procedure which does not use prophage induced lysis, and is potentially usable with B2 or EK2 safety systems, without modification of the bacterial hosts.
    Digital Access Access Options