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- BookAnthony J. Hickey, Hugh D.C. Smyth.Summary: Non-linear phenomena pervade the pharmaceutical sciences. Understanding the interface between each of these phenomena and the way in which they contribute to overarching processes such as pharmaceutical product development may ultimately result in more efficient, less costly and rapid implementation. The benefit to Society is self-evident in that affordable treatments would be rapidly forthcoming. We have aggregated these phenomena into one topic "Pharmaco-complexity: Non-linear Phenomena and Drug Product Development".
Contents:
Introduction
Chemistry and Thermodynamics
Solid State
Dynamics
Quality by Design
Pharmacokinetics and Pharmacodynamics
Poputaltion Biology
Machine Learning. - ArticleCoudray JP, Dufour H, Garello JL, Mollo Y, Pascal F, Poisson D, Scotto JC, Simart G, Sormani J, Tourame G.Nouv Presse Med. 1978 Jun 28;7(26):2333-8.Nomifensine and nortriptyline were compared in a collaborative trial by psychiatrists in private practice. The trial impiled:--selection of ambulatory depressed patients--randomization in parallel groups (respectively 31 and 34 subjects)--administration in double-blind condition of 4 capsuels daily of either compound during 4 weeks--quotation of depressvie syndrom with Hamilton depression scale before treatment after 2 and 4 weeks. The analysis of results shows clear improvment of depression scores, equivalent in both groups (non significant difference and posterior rejection of an alternative hypothesis). Practical problems encountered in controlled trials in psychiatrist's outpatients are discussed.