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  • Book
    edited by Kenneth K.W. To and William C.S. Cho.
    Summary: "Drug Repurposing in Cancer Therapy: Approaches and Applications provides comprehensive and updated information from experts in basic science research and clinical practice on how existing drugs can be repurposed for cancer treatment. The book summarizes successful stories that may assist researchers in the field to better design their studies for new repurposing projects. Sections discuss specific topics such as in silico prediction and high throughput screening of repurposed drugs, drug repurposing for overcoming chemoresistance and eradicating cancer stem cells, and clinical investigation on combination of repurposed drug and anticancer therapy"--Publisher's description.

    Contents:
    Drug repurposing for cancer therapy--an introduction
    A ligand-centric approach to identify potential drugs for repurposing: case study with aurora kinase inhibitors
    Machine learning strategies for identifying repurposed drugs for cancer therapy
    Unveiling potential anticancer drugs through in silico drug repurposing approaches
    Increasing opportunities of drug repurposing for treating breast cancer by the integration of molecular, histological, and systemic approaches
    The success story of drug repurposing in breast cancer
    A personalized medicine approach to drug repurposing for the treatment of breast cancer molecular subtypes
    Successful stories of drug repurposing for cancer therapy in hepatocellular carcinoma
    Stories of drug repurposing for pancreatic cancer treatment--Past, present, and future
    Animal models and in vivo investigations for drug repurposing in lung cancer
    Identification of chemosensitizers by drug repurposing to enhance the efficacy of cancer therapy
    Drugs repurposed to potentiate immunotherapy for cancer treatment
    Nanoparticle-based formulation for drug repurposing in cancer treatment
    Nanotechnological approaches in cancer: the role of celecoxib and disulfiram
    Clinical trials on combination of repurposed drugs and anticancer therapies.
    Digital Access ClinicalKey 2020
  • Article
    Mills D.
    Mol Gen Genet. 1978 Jun 14;162(2):221-8.
    Complete inhibition of sporulation was observed in two strains of Saccharomyces cerevisiae to which 8-hydroxyquinoline was added at a final concentration of 5 microgram/ml during the initial 4 to 6 h of sporulation. The cells were most sensitive to the inhibitor during 4 to 6 interval beginning at approximately 2 h (T2). Its addition during that interval resulted in 70 to 80% lethality in strain 4579 and about 40% in API at T24. When present from T0 onward, 5 microgram/ml of 8-hydroxyquinoline severely inhibited premeiotic DNA replication and reduced the frequency of intragenic recombination at the ade 2 and leu 2 loci by 70 and 100%, respectively, relative to control cultures which did not have the inhibitor present. During the period when the cells were most sensitive, the incorporation of 14C-leucine into protein and 14C-adenine into RNA was not inhibited nor was the polysome content affected. At 150 microgram/ml of inhibitor, incorporation of labeled precursors into RNA and protein were inhibited and the percentage of active ribosomes was reduced by 35% within 45 min, but neither transcription or translation appeared to be completely inhibited at this concentration of the inhibitor.
    Digital Access Access Options