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  • Book
    edited by Nuno Sampaio Gomes, Ladislav Kovačič, Frank Martetschläger, Giuseppe Milano.
    Summary: This book offers a truly comprehensive overview of the understanding and treatment of massive and irreparable rotator cuff tears, a painful and disabling shoulder condition that continues to pose major challenges. A thorough examination of basic science issues and evidence lays the foundation for discussion of key controversies in the field and exposition of a practical approach to treatment in which the role of both conservative and surgical management is explained. Special insights are provided into the new biological and nonoperative approaches that are becoming increasingly popular among practitioners. All potential surgical techniques are described, from partial repair and tendon transfer, to the use of dedicated implants. In addition, the value of anesthesia and regional blocks, both during surgery and in the postoperative phase, is discussed. The concluding section addresses particularly complex scenarios and offers guidance on the management of treatment complications and failures. Written by leading international shoulder experts, the book will be of value for shoulder surgeons, rehabilitators, and other health care practitioners.

    Contents:
    Part 1 Basic science
    Massive and irreparable rotator cuff tears: defining the problem
    Biology of rotator cuff injury and repair
    Biomechanics of rotator cuff repair
    Re-rupture or non-healing? Factors determining an unsuccessful repair
    Biological augmentation in rotator cuff repair: growth factors
    Biological augmentation in rotator cuff repair: cell therapies
    Biological augmentation in rotator cuff repair: scaffolds
    Imaging of repaired rotator cuff
    Part 2 Controversies in massive rotator cuff tears
    Clinical outcome vs structural integrity: what really matters?
    Fatty infiltration and muscle atrophy: what it means and what happens after repair
    Pseudoparalysis: Pathomechanics and clinical relevance
    Rotator cuff tear arthropathy: where are the limits for repair?
    Suprascapular nerve release: fact or fiction
    Traumatic cuff tears: the relevance of timing
    Critical shoulder angle: does lateral acromioplasty have a role in preventing re-rupture
    Shoulder injections: options, ultrasound assistance, evidences
    Non-operative Treatment: The Role of Rehabilitation
    Patient Expectation in the treatment of rotator cuff tears: what is its role?
    Treatment of massive irreparable cuff tears: decision-making process
    Part 3 Surgical techniques
    Partial repair
    Patch Graft Augmentation
    Superior capsule reconstruction
    Postero-superior Massive Irreparable Rotator Cuff Tears: The Biceps Autograft
    Tendon Transfer for Posterosuperior Cuff: Latissimus Dorsi Transfer
    Tendon Transfer for Posterosuperior Cuff
    Tendon Transfer for Posterosuperior Cuff: Latissimus Dorsi Transfer
    Tendon transfer for anterosuperior cuff: The Pectoralis Major Transfer
    Tendon transfer for anterosuperior cuff: Latissimus Dorsi Transfer
    Subacromial spacer
    Regional blocks and opioid sparing anesthesia: helping the surgeon and with patients satisfaction
    Part 4 Complex and revision problems
    Traumatic rotator cuff tears with sho ulder stiffness
    Management of bone loss in rotator cuff tear arthropathy
    Work-up and management of infection in shoulder arthroplasty
    Biomechanics of failure of reverse shoulder arthroplasty in rotator cuff tear arthropathy
    Revision of reverse total shoulder arthroplasty: humeral component
    Failure of Rotator Cuff Repair
    Combined massive rotator cuff and recurrent shoulder instability
    "Reverse arthroplasty VS other options"
    Cases examples
    Case example 4: Massive rotator cuff tear and patient specific rehabilitation in sportsmen.
    Digital Access Springer 2020
  • Article
    Law PY, Edelman IS.
    J Membr Biol. 1978 Jun 22;41(1):41-64.
    The possible induction of renal citrate synthase (E.C. 4.1.3.7) by aldosterone was evaluated in the adrenalectomized rat. Three hours after administration of aldosterone (0.8 microgram/100 g body wt), renal cortical and medullary citrate synthase activity was significantly increased as reported previously by Kinne and Kirsten (Kinne, R., Kirsten, R. 1968. Pfleugers Arch. 300:244). In contrast, no change in this activity was detected in the renal papilla or the liver, under the same conditions. Kinetic analysis revealed that injection of aldosterone had no effect on the KmS for acetyl-CoA and oxalacetate but augmented Vmax of renal medullary citrate synthase activity by 40%. The aldosterone-dependent increase in medullary citrate synthase activity was proportionate to the associated increase in the quantity of antiserum (specific for citrate synthase) required for half-maximal immuno-precipitation. The possibility that aldosterone induced the synthesis of citrate synthase was evaluated in two sets of experiments. In the first set, adrenalectomized rats were injected intraperitoneally with either aldosterone (0.8 microgram/100 g body wt) or the diluent, and simultaneously with 3H or 35S methionine (500 muCi/rat). The isotopes were reversed in about half of the experiments. Three hours after the injection, renal citrate synthase was isolated by ATP-sepharose column chromatography and immuno-precipitation with the specific antiserum. Aldosterone augmented methionine incorporation into renal citrate synthase by 55% but had no effect on incorporation into the hepatic enzyme. In the second set, adrenalectomized rats were injected with either aldosterone (0.8 microcram/100 g body wt) or the diluent, the kidneys were removed 1 hr later and medullary slices were incubated in either 3H- or 35S-methionine at 20 degrees for 2 hr. Mitochondrial citrate synthase was isolated either by ATP-sepharose column chromatography and immuno-precipitation, or by polyacrylamide gel electrophoresis. Aldosterone increased methionine incorporation into the immuno-precipitates by 30% and into the enzyme peak resolved by polyacrylamide gel electrophoresis by 43%. The latter increase was eliminated by prior administration of either actinomycin D (70--80 microgram/100 g body wt) or spirolactone (SC-26304) (80 microgram/100 g body wt). An equimolar dose of dexamethasone (0.8 microgram/100 g body wt) had no effect on the isotope ratio associated with citrate synthase activity in the polyacrylamide gels.
    Digital Access Access Options