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  • Book
    Liane Deligdisch-Schor, Angelica Mareş Miceli, editors.
    Summary: Hormonal influences, both natural and iatrogenic, are implicated in the most frequent health issues of women. Endometrial cancer is now the most common gynecologic cancer in the United States and the industrialized world. This cancer is strongly related to hormonal and metabolic factors. In addition, breast cancer treated with hormone therapy (Tamoxifen) may, in some cases, be associated with uterine pathology. Hormone therapy is used to improve the physiological effects and counteract abnormal and deleterious effects of "natural" hormonal activity. Millions of women receive hormone therapy at some point of their life: using oral contraceptives, reproductive technology, treatment for post-menopausal symptoms, among other uses. This book addresses a range of women's health issues, from fertility to neoplasms, and their relationship with natural and iatrogenic hormonal effects. Chapters include clinical and pathological descriptions, theoretical and practical medical issues, and original studies and cases. Controversial issues in certain hormone therapies are presented with updated concepts based on clinical studies and novel statistical methods. The book will be useful for specialized and general physicians, oncologists, endocrinologists, researchers, medical students, and others in the field of women's health.

    Contents:
    1. Biophysiology of the uterus: development, cyclic changes, menopause
    2. Hormonal effects in reproductive technology (ovulation stimulation, in vitro fertilization)
    3. Hormonal role and therapy in common benign uterine lesions: endometrial polyps, leiomyomas, adenomyosis
    4. Endometrial hyperplasia; precancerous lesions of the endometrium. Hormone therapy
    5. Endometrial Carcinoma. Endometriosis, Hormonal Role in Carcinogenesis. Hormonal Therapy
    6. Menopausal Hormone Therapy. Contraceptives
    7. Replacement hormone therapy for gender dysphoria and congenital sexual anomalies
    8. Hormone therapy for endometrial neoplasia related to breast cancer therapy (Tamoxifen)
    9. Endometrial histopatholigic changes in hormonal therapy (contraceptives, ovulation stimulation, hormone replacement therapy, hormonal antitumoral therapy).
    Digital Access Springer 2020
  • Article
    Rubio CA, Biberfeld P, Einhorn N.
    Histopathology. 1978 Jan;2(1):67-73.
    Basement membrane-specific antigens (BMSA) were found by immunofluorescence (IFL) in 20 of 33 tumour samples from patients with squamous carcinoma of the uterine cervix. The BMSA were demonstrated to be unrelated to condensation of both reticulin and subepithelial ground substance (as evidenced by antireticulin IFL antibodies, silver stain and PAS reaction, respectively), the age of the patient, the clinical stage and the histological differentiation of the tumour. The finding that BMSA secreting and non-secreting cervical tumours does not correlate with the degree of differentiation, was somewhat unexpected.
    Digital Access Access Options