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  • Book
    edited by Gab Kovacs, Monash University, Robert Norman, University of Adelaide.
    Summary: "In order to maximize the chance of IVF success, couples need to ensure that their preconceptual health is optimal to increase the quality of gametes and reproductive fitness. This text reviews the medical and lifestyle factors that can affect the body at preconception stage, such as micronutrients, stress, hormonal and gynecologic assessment, as well as environmental factors such as optimal weight and age for childbirth. This book will enable all medical practitioners and healthcare professionals to give evidence-based advice to influence the success rate of subsequent IVF cycles, and ensure that every child is born in the best possible condition. Part of a four-book series on optimizing different aspects of the IVF cycle, this book focusses on preparing the body for assisted conception. Other books in the series focus on the egg and embryo, the endometrium, and the sperm"-- Provided by publisher. "Nutrition and lifestyle choices hold implications for general health, as well as real and potential effects on fertility and reproductive health. While the effects of diet on health and risk of chronic disease have been well described, there is relatively little research on fertility per se. It is likely that the majority of men and women with sub-fertility, regardless of weight, have a form of intrinsic insulin resistance that underlies the downstream effects on oocyte and sperm quality (Dunaif, et al., 1989). Insulin resistance results in compensatory hyperinsulinaemia, which plays an important role in all the manifestations of sub-fertility, including androgen excess, inflammation and anovulation in women with polycystic ovarian syndrome (PCOS)"-- Provided by publisher.

    Contents:
    Machine generated contents note: 1. The effects of nutrition and micronutrients on reproductive success Mu Li, Kyra Sim, Adrienne Gordon and Jennie Brand-Miller; 2. The effects of stress on conception and pregnancy Jeremy J. Cottle, Jacky Boivin and Alice D. Domar; 3. Preparing for IVF: an endocrine perspective Clare Bothroyd; 4. Assessment of endometriosis before conception Endah Rahmawati, Chien-Wen Chen, Yu-Wen Chen, Chang-Chih Hsieh, Pei-Chun Ma, Shun-Jen Tan and Chii-Ruey Tzeng; 5. Assessment of pelvic abnormalities prior to assisted reproduction Anusch Yazdani; 6. Immunological preparation, including vaccinations and microbiome management, prior to ART Ashley Gilman and William Buckett; 7. Optimising body weight to improve reproductive success Kelton Tremellen; 8. Lifestyle modifications
    alcohol, caffeine, smoking, drugs before ART V. Nisenblat and M. Johnson; 9. Environmental factors to consider prior to conception Mark P. Green and Alexandra J. Harvey; 10. Pre-pregnancy genetic carrier screening Saioa Torrealday, Kyle J. Tobler and Pasquale Patrizio; 11. The optimal age for childbearing Rina Fyfe and Jon Hyett; 12. Alternative therapies to improve conception rates Caroline A. Smith and Mike Armour; 13. Preconception lifestyle modification of decidua to decrease early pregnancy loss: feeding the endometrium Alexandra Kermack, Ka Ying Bonnie Ng and Nick Macklon; 14. Antenatal factors that may contribute toward the development of polycystic ovary syndrome Roy Homburg and Panagiota Filippou.
    Digital Access Cambridge 2018
  • Article
    Nillius SJ, Bergquist C, Wide L.
    Contraception. 1978 Jun;17(6):537-45.
    A stimulatory luteinizing hormone-releasing hormone (LRH) analogue D-Ser(TBU)6-EA10-LRH was administered subcutaneously once daily in a dose of 5 microgram to four regularly menstruating women. Treatment was instituted within the first three days of the menstrual bleeding and continued for 22--30 days. Ovulation was inhibited in all the women during the treatment cycle. The treatment resulted in disturbances in the pituitary gonadotropin secretion which presumably led to disordered follicular menuration and anovulation. The maximum follicle-stimulating hormone (FSH) and luteinizing hormone (LH) responses to the LRH analogue were obtained during the first few days of treatment. The gonadotropin responses then rapidly decreased during the prolonged treatment. This change in the pituitary responsiveness probably prevented the release of a normal preovulatory LH surge. After the treatment, all the women resumed normal ovulatory menstrual cycles. The results suggest that it might be possible to use stimulatory LRH analogues for birth control.
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