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- Bookedited by Stephanie Duggins Davis, Margaret Rosenfeld, James Chmiel.Summary: This book provides a comprehensive overview of the multisystem disease, cystic fibrosis, for both pediatric and adult patients. Written by experts in the field, the text outlines the progressive nature of CF as well as the impact of this autosomal recessive disease on the respiratory, gastrointestinal, endocrine, rheumatologic, and renal systems, as well as the patients mental health. The book begins with a chapter describing the history of cystic fibrosis and how the face of this life-shortening disease has changed over the past several decades. The following chapters elucidate the pathophysiology of how cystic fibrosis impacts each organ system. Current management and therapeutics are detailed with step-by-step guidelines for clinicians. This book is unique in that it highlights the entire person, not just the respiratory system, with detailed inclusion of the patient perspectives throughout, informing practice standards and considerations. This is an ideal guide for pediatric and adult physicians who care for patients with cystic fibrosis, as well as respiratory therapists, physical therapists, nurses, nutritionists, and pharmacists who care for these patients.
Contents:
The Changing Face of CF
Diagnosing cystic fibrosis
SECTION I: Pulmonary Manifestations
Early lung disease
Pulmonary complications as an adult
Treating respiratory complications
Transplant
SECTION II: Gastrointestinal Manifestations
Liver disease
Pancreatic insufficiency and nutritional complications
SECTION III: Endocrine Manifestations
Diabetes
Bone Disease. SECTION IV: Further Comorbidities
Rheumatologic Manifestations
Reproductive Issues
The Impact of CF on the Kidney
Mental Health.Digital Access Springer 2020 - ArticleFerrans VJ.Cancer Treat Rep. 1978 Jun;62(6):955-61.A review is presented of cardiac pathologic changes associated with acute and chronic toxicity of anthracyclines. These changes consist of cardiac dilatation, degeneration and atrophy of the muscle cells, and interstitial edema and fibrosis. The degeneration of cardiac muscle cells is a complex phenomenon that involves the myofibrils, the nucleus, the mitochondria and the membrane systems of the T-tubules, the sarcoplasmic reticulum, and the intercellular junctions. The pathogenesis of these alteration is discussed in terms of the biochemical effects of anthracyclines.