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  • Book
    edited by Tsuneo Imanaka, Nobuyuki Shimozawa.
    Summary: This book provides readers with a comprehensive overview of peroxisomes and their role in human diseases. It starts by describing the history of peroxisome research and then examines in detail the current understanding of the biogenesis and function of peroxisomes. It then focuses on peroxisomal disorders and the involvement of peroxisomes in cancer and age-related diseases, discussing in detail the use of model organisms to elucidate the pathogenesis of peroxisomal disorders and the physiological importance of peroxisomal proteins. Further, the book examines diagnostic and therapeutic strategies in peroxisomal disorders as well as significant recent advances. Lastly, it addresses various topics in peroxisome research, including the isolation of peroxisomes from mammalian tissues and cells, the structural biology of peroxisomal proteins, the lipidomics of peroxisomal disorders, the value of exome sequencing, and neuropsychological testing in X-linked adrenoleukodystrophy. Given its scope, the book is a valuable resource for postgraduate students and researchers in the life sciences and clinicians in the fields of internal medicine, pediatrics, and neurology.

    Contents:
    Part 1 Biogenesis and Function of peroxisome
    1 The history of peroxisomal research
    2 Peroxisome Biogenesis
    3 Peroxisome Degradation and Its Molecular Machinery
    4 The function of the peroxisome
    Part 2 Dysfunction of Peroxisome and Human Disease
    5 Peroxisomal disorders
    6 Model organisms used to understand peroxisomal disorders
    7 Diagnosis of peroxisomal disorders
    8 Therapeutic strategies for X-linked adrenoleukodystrophy, a representative peroxisome disease
    Part 3 Topics in Peroxisome Research
    9 The isolation of peroxisomes
    10 Structure Biology of peroxisomal proteins, peroxins
    11 Lipidomics of peroxisomal disorders
    12 Neurophysiology and neuropsychology for X-ALD.
    Digital Access Springer 2019
  • Article
    Hellman B, Andersson T.
    Biochim Biophys Acta. 1978 Jul 17;541(4):483-91.
    beta-Cell-rich pancreatic islets were microdissected from ob/ob-mice and used for studies of 45Ca uptake and washout. Irrespective of whether the experiments were performed at 21 or 37 degrees C both glucose and phosphate stimulated the net uptake of lanthanum-nondisplaceable 45Ca. The stimulatory effect of phosphate was additive to that produced by glucose. 45Ca incorporated in response to phosphate differed from that taken up in the presence of 20 mM glucose in being easily washed out although it was not affected by the glucose concentration of the washing medium. The efflux of 45Ca was reduced after introducing phosphate into a medium used to perifuse islets which had accumulated 45Ca in response to 20 mM glucose. This suggests that the outward calcium transport can be influenced also by intracellular trapping of the cation. The glucose-stimulated insulin release was inhibited by phosphate; an effect reversed by the phosphodiesterase inhibitor 3-isobutyl-1-methylxanthine. It is concluded that a common effect of glucose and phosphate is to trap calcium in the pancreatic beta-cells but that there are fundamental differences between their effects on intracellular distribution of calcium and on insulin release.
    Digital Access Access Options