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  • Book
    Sameek Roychowdhury, Eliezer M. Van Allen, editors.
    Summary: This comprehensive book was written by leading researchers in the emerging and changing field of precision cancer medicine. Precision cancer medicine entails connecting the right molecular diagnosis to the right treatment plan for individual patients. The textbook covers a range of topics from basic science to clinical application for patient care. Precision cancer medicine includes multi-disciplinary fields of research expertise ranging from genomics, pathology, oncology, hereditary genetics, bioinformatics, immunology, cancer biology, and bioethics. Basic topics include molecular diagnostics, liquid biopsy, immunogenomics, drug resistance mechanisms, and bioinformatics analyses of big data. The clinical topics include clinical interpretation, hereditary cancers, designs of basket clinical trials, exceptional responders, and the ethical, legal, and social implications of clinical genomics research. Readers who are involved in one of the specialities of precision cancer medicine can benefit from this book through exposure to other fields. Any level of training or professional practice can benefit from the broad exposure this book can provide.

    Contents:
    Preface
    Between Hype and Hope, on the Cutting Edge of Precision Cancer Medicine
    Molecular Diagnostics in Cancer: a Fundamental Component of Precision Oncology
    Clinical Interpretation
    Precision Cancer Medicine and Clinical Trial Design
    Resistance to Anti-Cancer Therapeutics
    Exceptional Responders
    Immunogenomics
    Managing Germline Findings from Molecular Testing in Precision Oncology
    Ethical, legal, and social implications of precision cancer medicine
    Liquid Biopsy: Translating Minimally Invasive Disease Profiling From The Lab To The Clinic
    Data Portals and Analysis
    Index.
    Digital Access Springer 2019
  • Article
    Riazuddin S, Lindahl T.
    Biochemistry. 1978 May 30;17(11):2110-8.
    An Escherichia coli enzyme that releases 3-methyladenine and 3-ethyladenine in free form from alkylated DNA has been purified 2800-fold in 7% yield. The enzyme does not liberate several other alkylation products from DNA, including 7-methylguanine,O6-methylguanine, 7-methyladenine, N6-methyladenine, 7-ethylguanine, O6-ethylguanine, and the arylalkylated purine derivatives obtained by treatment of DNA with 7-bromomethyl-12-methylbenz[a]anthracene. The reaction of the enzyme with alkylated DNA leads to the introduction of apurinic sites but no chain breaks (less than one incision per ten apurinic sites), and there is no detectable nuclease activity with native DNA, depurinated DNA, ultraviolet-irradiated DNA, or X-irradiated DNA as potential substrates. The enzyme is termed 3-methyladenine-DNA glycosylase. It is a small protein, Mr = 19 000, that does not require divalent metal ions, phosphate, or other cofactors in order to cleave base-sugar bonds in alkylated DNA.
    Digital Access Access Options