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- BookYashwant V Pathak, editor.Summary: This unique book discusses various new techniques developed to enhance the application of nanoparticulate drug delivery systems using surface modification of nanoparticles. The understanding of the surface characteristics of nanoparticles is growing significantly with the advent of new analytical techniques. Polymer chemistry is contributing to the development of many new versatile polymers which have abilities to accommodate many different, very reactive chemical groups, and can be used as a diagnostic tool, for better targeting, for more effective therapeutic results as well as for reducing the toxic and side effects of the drugs. Surface modification of such polymeric nanoparticles has been found by many scientists to enhance the application of nano-particles and also allows the nanoparticles to carry specific drug molecule and disease /tumor specific antibodies which refine and improve drug delivery. Surface Modification of Nanoparticles for Targeted Drug Delivery is a collection of essential information on various applications of surface modification of nano-particles and their disease specific applications for therapeutic purposes.
Contents:
Intro; Foreword: Nanobiotechnology Convergence for Drug Delivery; Preface; Contents; Contributors;
Chapter 1: Understanding Surface Characteristics of Nanoparticles; 1 Introduction; 2 Characterization of Nanoparticles; 2.1 Electron Microscope; 2.2 X-Ray Diffraction; 2.3 Infrared/Visible Spectroscopy and Photoluminescence; 3 Synthesis of Nanoparticles; 3.1 Gas-Phase Synthesis; 3.2 Liquid-Phase Synthesis; 3.3 Solid-Phase Synthesis; 4 Applications of Nanoparticles; 4.1 Drug Delivery; 4.2 Tissue Engineering; 4.3 Nonbiological Applications; 5 Conclusion; 6 Future Trends; References 4.3 The "Click Chemistry"5 Work Explored by Various Researchers for Targeting of PLGA NPs to Brain in Different Neuronal Diseases; 6 Patents and Clinical Trial Status; 7 Concluding Remarks and Future Perspectives; References;
Chapter 4: Surface-Functionalized Lipid Nanoparticles for Site-Specific Drug Delivery; 1 Introduction; 2 Lipid-Based NPs; 3 Parameters Affecting the In Vivo Fate of Lipid NPs; 3.1 Influence of Particle Size; 3.2 Influence of Surface Charge; 3.3 Influence of Hydrophobicity; 4 Passive Targeting Based on Pegylation; 5 Active Targeting 5.1 Functionalization with Antibody Ligands5.2 Functionalization with Saccharide ligands; 5.3 Functionalization with Transferrins; 5.4 Functionalization with Cell-Penetrating Peptides; 5.5 Functionalization Based on Avidin-Biotin Affinity; 5.6 The Antiangiogenic Strategy; 6 Conclusions; References;
Chapter 5: Stealth Properties of Nanoparticles Against Cancer: Surface Modification of NPs for Passive Targeting to Human Cancer Tissue in Zebrafish Embryos; 1 Cancer: Introduction, History, Geographical Distribution, and Causes
Chapter 2: Surface Modification of Nanoparticles for Targeted Drug Delivery1 Introduction; 2 Surface Modification Using Cobalt Oxide Nanoparticles for Targeted Drug Delivery in Anticancer Treatments; 3 Use of Bromelain for Surface Modification of Silica Nanoparticles for Drug Delivery in the Tumor Extracellular Matrix; 4 Surface Modification of MPEG-B-PCL Nanoparticles for Malignant Melanoma Therapy; 5 Nanoparticles for Cellular-Based Applications of Stavudine; 6 Toxicopharmacological Aspects; 7 Conclusion; References
Chapter 3: Surface-Modified PLGA Nanoparticles for Targeted Drug Delivery to Neurons1 Introduction; 1.1 Neuronal Diseases; 1.2 Introduction to Various Neuronal Diseases; 1.2.1 Alzheimer's Disease (AD); 1.2.2 Parkinson's Disease (PD); 1.2.3 Brain Cancer/Brain Tumors; 1.3 Blood-Brain Barrier (BBB); 1.4 Nasal Drug Delivery to Brain; 2 Nanoparticles as Drug Delivery Vehicles; 3 Dual-/Multi-targeting Strategies; 3.1 Lectins; 3.2 Cell-Penetrating Peptides (CPPs); 3.2.1 Glutathione (GSH); 4 Strategies for Targeted Nanoparticles; 4.1 Carbodiimide Chemistry; 4.2 Michael Addition - ArticleBr J Ophthalmol. 1978 Jun;62(6):345-6.